Biological And Immunological Effects of Ammi Visnaga Seeds on Diabetic Rats

Abstract

Ammi visnaga seeds have potential immune-modulating effects, where they increase white blood cell counts and enhance antibody production. The seeds also exhibit antioxidant and anti-inflammatory properties, which are key to a healthy immune response.

Aim: This study aimed to determine the  biological and immune

logical effects of Ammi visnaga seeds on diabetic rats.

Materials and Methods: Thirty-six male Sprague Dawley rats were divided into normal (n=6) and diabetic (n=30). The second group was injected with streptozotocin (at a dose of 75 mg/ kg intraperitoneally), and those with blood glucose concentrations more than 250 mg/dL were classified as diabetic. Rats were divided into six groups, (1) non-diabetic group (n=6) received distilled water (2 mL/ day); (2) diabetic control group (n=6) received distilled water (2 mL/ day); (3) diabetic group (n=6) received basal diet +5% Ammi visnaga; (4) diabetic group (n=6) received basal diet +10% Ammi visnaga; (5) diabetic group (n=6) received basal diet +15% Ammi visnaga.(6)  diabetic group (n=6) received a basal diet +20% Ammi visnaga. After 28 days, blood was collected, and serum was extracted to determine Blood Parameters ( RBC, Hgb, MCV, RDW, HCT, MCH , MCHC ,WBC, LYM)

Results: At the end of the experiment, the best group for WBC, LYM, PLT, MID & GRAN was that of the group 6 ( 20% Ammi visnaga).

Conclusion: Ammi visnaga seeds hold significant potential as a natural aid in boosting immune health and promoting overall well-being. These findings suggest that Ammi visnaga seeds may hold promise for developing new treatments for human diabetes.