Association of Serum Adiponectin and Urinary Nephrin for Identification of Nephropathy in Patients with Type 2 Diabetes Mellitus

Abstract

Introduction: Adiponectin is an adipose tissue secreted protein and nephrin is a podocyte secreted protein. Both protein link with the mechanism involved in the pathophysiology of type 2 diabetes mellitus and nephropathy. 

Objectives: The present study aimed to evaluate the serum adiponectin and urinary nephrin for early detection of nephropathy in patients with type 2 diabetes mellitus.

Methods: This case control study using serum samples obtained from 160 participants, controls (40), normo albuminuria (40), micro albuminuria (40), macro albuminuria (40). This biochemical, clinical, and experimental parameter were analysed statistical analysis were done by SPSS 20.0 software.

Results: Serum adiponectin and urinary nephrin levels in type 2 diabetes mellitus groups are very high and significant when compared to controls. The urinary nephrin and serum adiponectin levels significant positively corelated with urinary albumin creatinine ratio and significant and negatively corelated with eGFR (P=0.001**). The ROC curve analysis reviled the serum adiponectin and urinary nephrin very high in significant at area under curve with sensitivity (100.00 and 77.50) and specificity (100.00 and 100.00) with P value 0.001**.

Conclusions: Based on the study findings the serum adiponectin determination beneficial for the patients with type 2 diabetes mellitus. The measurement of urinary nephrin served as an early predictable and prognostic marker for nephropathy in patients with type 2 diabetes mellitus.