Correlation of Serum Magnesium with Clinical Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus

Abstract

Introduction: The type 2 diabetes mellitus clinical disease is typified by hyperglycemia, or elevated blood glucose levels, brought on by insufficient or ineffective (incompetent) insulin. The magnesium is the fourth most prevalent cation and has numerous essential biological functions, such as DNA synthesis and metabolism.

Objectives: The present study aimed to correlate the Serum Magnesium and Clinical Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus.

Methods: The present study included 150 T2DM patients and 75 age, gender matched healthy controls, the T2DM cases classified into two groups based on their microalbumin levels. For all the patients routine biochemical, clinical and serum magnesium was analysed.

Results: The serum magnesium had shown significant reduced levels in patients with T2DM when compared to controls. These levels significantly negatively correlated with blood sugars, glycated haemoglobin, dyslipidaemia, urinary ACR and these levels positively correlated with HDL and GFR. The ROC curve analysis also shown the serum magnesium has significant at area under the curve, also has highest sensitivity and specificity than urinary ACR and eGFR.

Conclusions: This study suggests to monitor serum magnesium might be useful for to detect early onset of nephropathy in patients with T2DM and controls.