Unveiling the Therapeutic Manifold of Lagerstroemia Speciosa (L.) Pers.: Insights on In-Vitro Antioxidant, Anti-Inflammatory, And Anticholinesterase Activities

Abstract

Introduction: A wide range of medicinal pharmacological properties against acute and chronic diseases have been demonstrated by numerous medicinal plant bioactive extracts and their identified active constituents.

Objectives: This study assesses the antioxidant, anti-inflammatory, and anti-cholinesterase properties of successive extracts derived from Lagerstroemia speciosa at varying concentrations in order to determine their potential medical utility.

Methods: For extraction, the Soxhlet extraction technique was utilised. Moreover, free radical scavenging, hemolytic inhibitory, protein denaturation, and cholinesterase inhibition assays were investigated to measure the pharmacological activities.  

Results: The phytochemical levels in the methanol extract were higher than those in the other extracts. All the extracts showed percentage inhibition dose-dependently. Comparatively, methanol extract possessed better anti-oxidant and anti-inflammatory properties. Subsequently, at concentrations (6.25-200 µg/mL), methanol extract dose-dependently inhibited acetylcholinesterase (AChE), and butrylcholinesterase (BuChE). The IC₅₀ values were determined to be 36.02 ± 0.62, and 64.58 ± 1.48 µg/mL (p < 0.001), respectively.

Conclusions: Thus, methanol extract should be further evaluated in search of other phytochemicals, and the in-vitro studies should be validated through in-vivo animal models.