Correlation of Urinary 8-Hydroxy-Deoxyguanosine with Clinical Markers of Nephropathy in Patients with Type 2 Diabetes Mellitus

Abstract

Introduction: Kidney problems is most common in patients with Type 2 Diabetes Mellitus. For detection of kidney problems need a sensitive and specific marker.

Objectives: Present study aimed to Correlate urinary 8-hydroxy-deoxyguanosine with clinical markers of nephropathy in patients with Type 2 Diabetes Mellitus.

Methods: This cross-sectional analytical study included 180 Type 2 Diabetes Mellitus patients and 60 controls. For all the study subjects we analysed fasting blood sugar, HbA1c, lipid profile, urinary albumin creatinine ratio, eGFR, serum magnesium, and urinary 8OHdG.

Results: There was significantly decreased serum magnesium levels in all the groups of Type 2 Diabetes Mellitus patients when compared to controls. There was significantly increased urinary 8-hydroxy-deoxyguanosine levels in all the groups of Type 2 Diabetes Mellitus patients when compared to controls. Additionally, the serum magnesium negatively corelated with urinary albumin creatinine ratio and 8-hydroxy-deoxyguanosine and positively corelated with eGFR. Similarly, 8-hydroxy-deoxyguanosine positively corelated with urinary albumin creatinine ratio and serum magnesium and negatively corelated with eGFR.

Conclusions: Based on study results determination of magnesium beneficial for type 2 diabetes mellitus  patients and urinary 8-hydroxydeoxyguanosine might be used as early predictive and prognostic marker for nephropathy in type 2 diabetes mellitus  patients.