The Role of Positive Acute Phase Protein (Ferritin) In Chronic Kidney Disease

Abstract

Background: Renal failure is a major health issue, which has been increasing worldwide [1]. Oxidative stress and inflammation are associated with higher risk of chronic kidney disease (CKD). Serum ferritin concentrations correlate with systemic inflammation, found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Ferritin concentrations increase drastically in the presence of an infection. The aim of this (Retrospective) study is to know the associations between serum ferritin levels and CKD.

Method: Chemiluminescence.

Results: A total No of 100 cases (Retrospective) were studied by dividing them into two group’s controls (50) and cases (50). The results so obtain were compared with 50 healthy controls Statistical evaluation was carried out to confirm any deviation from the normal values.The mean serum FERRITIN values in cases is having higher level as compared to the mean value of controls This increase (Ferritin <0.0001) is statistically highly significant.

Conclusions: where ferritin is elevated in its capacity as an inflammatory acute phase protein and not as a marker for iron overload.CKD can disrupt normal iron metabolism and lead to inflammation, it is clear that ferritin serves as a vital biomarker.