Investigation on Synthesis and Etymology of Antifungal Action of Triazole Compounds by Coupling of Pyrimidine with Hydrazine Carbothioamide

Abstract

Sequences of triazole-included pyrimidine compounds were synthesized via a multi-step process under mild and convenient conditions, affording reasonable to high yields. The structures of the synthesized selected compounds were confirmed by elemental analysis, GC-MS, ¹H and ¹³C NMR, FT-IR, and CHN analysis. Further, biological assessment revealed that most of the compounds unveiled prominent antifungal activity, with compounds 3a and 3g demonstrating the most promising inhibition, comparable to the standard drug Amphotericin-B. This kind of biological active antifungal action of triazole compounds have wide potential applications in medical environment.