Diamino Acid-Tetrazole Derivatives: Antihypertensive and Antimicrobial Investigation.

Abstract

Background: Recent research for new antihypertensive drugs has been intensively attempted because of the high rate of morbidity and several side effects that are associated with first-line medications among hypertensive patients.

Objective: The current study investigates the antihypertensive and antibacterial effects of newly synthesized diamino acid-functionalized biphenyl tetrazole derivatives.

Result: Among the synthesized tetrazole derivatives, six selected compounds were investigated for antihypertension activity. In vivo experiments were conducted on male albino Wistar rats against the standard drug, telmisartan. Compounds Biphenyl Tetrazole Isonipecotic L-Alanine Isonipecotic–OH (BPT-Inp-Ala-Inp-OH), Biphenyl Tetrazole Isonipecotic L-Phenylalanine Isonipecotic–OH (BPT-Inp-Phe-Inp-OH), and Biphenyl Tetrazole Isonipecotic L-Leucine Isonipecotic–OH (BPT-Inp-Leu-Inp-OH) were found to have excellent activity. Whereas, compound Biphenyl Tetrazole Isonipecotic Glycine Isonipecotic–OH (BPT-Inp-Gly-Inp-OH) showed moderate Antihypertensive activity, and the remaining compounds, Biphenyl Tetrazole Isonipecotic L-Tyrosine Isonipecotic–OH (BPT-Inp-Tyr-Inp-OH), Biphenyl Tetrazole Isonipecotic L-Valine Isonipecotic–OH (BPT-Inp-Val-Inp-OH), exhibit less activity.

Significance: We observed that antihypertensive and antimicrobial activity investigations are correlated with electrical and structural properties of the compounds.

Conclusion: This study will contribute to the understanding of the correlation between activity and structural assessment of the compound.