Green synthesis and characterization of silver nanoparticle using M.indica and their anticancer activity against MCF-7
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Abstract
This work provides a safe, affordable and eco-friendly method for synthesizing silver nanoparticles (AgNPs) from leaves of Mangifera indica. The noticeable shift in colour from pale yellow to reddish-brown signifies a fast synthesis of AgNP. Validation of AgNPs was confirmed by a UV-Visible spectrum, FTIR, and DLS analysis. X-ray diffraction confirms the crystalline nature of AgNPs, and FESEM images show spherical, agglomerated nanoparticles. EDX analysis confirms metallic silver with elemental constituents of 50.03% silver and 49.97% oxygen, affirming successful silver ion reduction, that indicates good efficacy of M. indica leaf extract as a capping agent. AgNPs exhibited good inhibition zone against E. coli, Streptococcus sp, and Staphylococcus sp (15 mm, 13 mm & 14 mm). AgNPs indicating potent cytotoxicity on MCF-7 breast cancer cells, with a significant 14% reduction in cell viability at 250 μl.