Comparison of the Two Different Formulations of Propofol I.E. Propofol 1% (Long Chain Triglyceride) With Propofol Lipuro 1% (Medium Chain Triglyceride +Long Chain Triglyceride) As an Induction Agent for Elective Short Surgical Procedures: A Study from Ter

Abstract

Introduction: The rapid return of psychomotor functions has made propofol an anaesthetic agent of choice for day care surgeries. The more rapid return of consciousness with minimal residual central nervous system effects is one of the most important advantages of propofol compared with alternative drugs administered for the same purpose. The context-sensitivity half time of propofol is very short even with prolonged periods of infusion combined with short effect site equilibration time, which makes this drug an intravenous agent of choice for maintenance of anaesthesia and for intravenous sedation.

Objective: To compare the two different formulations of Propofol i.e. Propofol 1% (long chain triglyceride) with Propofol lipuro 1% (medium chain triglyceride +long chain triglyceride) as an induction agent for elective short surgical procedures.

Results: 62.0% of patients have pain on injection with standard Propofol while 38.0% of patients have pain on injection with Propofol lipuro. By applying chi-square test p value was 0.01 which was statistically significant. Total dose for induction in standard Propofol group was 123.60±20.678 (MEAN±SD) and in Propofol lipuro group was 120.00±14.142 (MEAN±SD) sec. It was not statistically significant.

Conclusion: In this study on hundred healthy subjects, we found that, the new formulation of Propofol (Propofol lipuro 1%- medium chain triglyceride + long chain triglyceride) was well tolerated and generally indistinguishable from standard Propofol 1% (long chain triglyceride). However, we did find a significant decrease in the incidence of pain on injection with new formulation of Propofol.

Conclusion: Propofol 1% (long chain triglyceride) with Propofol lipuro 1% (medium chain triglyceride +long chain triglyceride), elective short surgical procedures