Comparing the Efficacy of Iron sucrose with Ferric carboxy maltose in Post partum iron deficiency anemia -A Prospective Observational Study

Abstract

Introduction: Anaemia is the most common disorders of blood, affecting about a quarter of the people globally. Iron deficiency anaemia affects nearly one billion people. So, the study was conducted to compare efficacy of iron sucrose therapy with ferric carboxymaltose intravenously in post-partum iron deficiency anemia.

Objectives: To compare the effect of iron sucrose with ferric carboxy maltose in postpartum iron deficiency anemia.

Methods: It was a prospective observational study conducted in the Department of obstetrics and gynecology, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla, Odisha, India. The study was held from November 2017 to October 2019. Total 123 patients with iron deficiency anemia on postpartum day 2 were enrolled in the study.

Results: The mean age of participants of iron sucrose therapy group was 24.5±11.3 and that of FCM group was 25.6±10.1. Mean BMI in iron sucrose treated group was 20.16 ± 2.51and in FCM treated group was 20.11 ± 3.4. In injectable iron sucrose therapy group on 6^th week, mean haemoglobin was 9.96±0.74 and in injectable FCM therapy group it was 101.85±1.14 with p-value <0.001. Similarly, the mean serum ferritin level in the iron sucrose therapy group was 102.67 ± 28.42, compared to 185.43 ± 33.25 in the FCM therapy group, also with a p-value of < 0.001. The mean haemoglobin and serum ferritin levels in the FCM therapy group were significantly higher than those in the iron sucrose therapy group (p < 0.001) which was statistically significant.

Conclusions: From our study we concluded that, Ferric carboxy maltose was more effective in correcting postpartum IDA than iron sucrose.