Study of TSH Dysfunction Associated with Metabolic Disorders in adult Indian Population : A Clinical Prospective study

Abstract

Background:

Thyroid disorders rank among the most prevalent endocrine disorders worldwide. India is not an exemption either. All organ systems are impacted by thyroid diseases, which lower quality of life and increase long-term morbidity. Thyroid hormone changes have an impact on the respiratory system as well. They result in ventilation abnormalities respiratory disease & metabolic dysfunctions.

Aims and Objectives: In this study the pattern of metabolic dysfunctions to be observed with thyroid dysfunction.

Materials and Methods: We started this case-control observational study after receiving approval from the institutional ethical council. The study involved 100 individuals in total: 60 euthyroid controls and 40 thyroid problem patients (hypothyroid = 30 and hyperthyroid = 10). The study employed a convenient sampling technique, while the control groups were chosen using a basic random sample technique. The thyroid profile was then evaluated by using test device. Thereafter experiment has been performed and the data analysed by using SPSS version 20.0 (Chicago InL).

Results:

In euthyroids, hypothyroids, and hyperthyroids, the corresponding forced expiratory volume in 1 (FEV1)/forced vital capacity (FVC) was 81.73 ± 1.09, 82.16 ± 2.30, and 81.3 ± 1.75. FVC was 3.18 ± 0.63 in euthyroids, 2.66 ± 0.45 in hypothyroids, and 2.45 ± 0.36 in hyperthyroids. Patients with hypothyroidism exhibited a restrictive pattern, but hyperthyroid patients' PF did not differ significantly from those of euthyroid patients. For both hyperthyroid and hypothyroid patients, we discovered a positive linear relationship between FEV1 and TSH (r = 0.52 and r = 0.17, respectively).

Conclusion: In hypothyroid patients, our analysis reveals a restrictive pattern with elevated FEV1/FVC, while in hyperthyroid individuals, we were unable to identify any statistically significant variations in PFT.