A Study on Evaluation of In-Vitro Antidiabetic Activities of Endangered Plant Species Syzygium Travancoricum of the Western Ghats

Abstract

Diabetes mellitus is a complex, irreversible metabolic illness that affects insulin secretion, function, or both, and raises blood sugar levels. Even now, acarbose and voglibose, either alone or in combination with insulin are used as inhibitors of the enzymes that break down carbohydrates. Nevertheless, these substances have been linked to adverse side effects. Therefore, this study aimed for evaluation of in-vitro antidiabetic activities of some endangered plant species collected from the western ghats. Results revealed that the stem extract of Syzygium travancoricum at a concentration range of 0.0781μg/mL, 0.1562μg/mL, 0.3125μg/mL, 0.625μg/mL, 1.250μg/mL, and 2.500μg/mL showed inhibition effect of 30.66%, 46.59%, 54.20%, 71.83%, 75.73%, and 82.17% respectively in alpha-glucosidase inhibition activity. The IC50 value of stem extract of S. travancoricum in alpha-glucosidase inhibition activity was found to be 150.10μg/mL in comparison with the standard antidiabetic drug acarbose with an IC50 value of 0.19μg/mL. Similarly, stem extract of S. travancoricum at a concentration range of 0.0781μg/mL, 0.1562μg/mL, 0.3125μg/mL, 0.625μg/mL, 1.250μg/mL, and 2.500μg/mL showed inhibition effect of 30.48%, 46.49%, 54.06%, 71.72%, 75.72%, and 82.12% respectively in alpha-glucosidase inhibition activity. The IC50 value of stem extract of S. travancoricum in alpha-amylase inhibition activity was found to be 48.38μg/mL in comparison with the standard antidiabetic drug acarbose with an IC50 value of 0.19μg/mL. In conclusion, stem extract of S. travancoricum exhibited considerable anti-diabetic properties, and hence this study supports the employment of stem extract of S. travancoricum in the development of antidiabetic medicinal drugs.