Exploring Senna Alata Bark as a Potential Therapeutic agent for Wound Healing: A Comprehensive Pharmacognostic, Physicochemical, Phytochemical, & Pharmacological Study

Abstract

Wound healing is a complex biological process crucial for tissue repair following injury, involving sequential phases of hemostasis, inflammation, proliferation, and maturation. Senna alata (L.) Roxb., commonly known as candle bush, is a flowering shrub with recognized medicinal properties. This study explored the Pharmacognostic, physicochemical, phytochemical, and pharmacological characteristics of Senna alata bark, aiming to assess its potential as a therapeutic agent in wound care. Macroscopic and microscopic analyses confirmed the identity of Senna alata, revealing characteristic features such as light green color and distinct odors. Physicochemical evaluations demonstrated favorable parameters including low moisture content and significant extractive values, supporting its suitability for medicinal formulations. Hydroalcoholic extracts of Senna alata were enriched with bioactive compounds including steroids, flavonoids, and alkaloids, identified through phytochemical screening. The extracted components were utilized to formulate a gel preparation, demonstrating good consistency and stability suitable for topical application. Pharmacological investigations using an excision wound model in rats showed that Senna alata formulations facilitated accelerated wound healing compared to control groups, as evidenced by enhanced wound contraction rates over a 15-day period. These findings underscore the potential of Senna alata as a promising herbal remedy for promoting wound healing. To fully use its therapeutic potential, more investigation into its mechanisms of action and wider clinical applications is necessary. benefits.