To Explore Nootropic Activity of Artemisia roxburghiana Ethanolic Leaf Extract on Wister Rats.

Abstract

Introduction:Progressive cognitive impairment is the hallmark of dementia, which invariably causes problems with all knowledge-based tasks.It often begins with an impairment in the ability to acquire new memories.An ethanolic extract from Artemisia roxburghiana (Asteraceae) leaves was tested for its effects about memory and learning using the Y-maze test, locometer activity, and brain histology.Rats were given the ethanolic leaf extract orally at two different dosages (100 mg/kg and 400 mg/kg) for seven days.

Objectives:To explore Nootropic activity of Ethanolic extract of Artemisia roxburghiana leaves on  wistar rats.

Methods:In this study we used thirty female wister rats in five groups each group contains six  rats  animals were given doses of ethanolic leaf extract of artemisia roxburghiana 100mg/kg and 400mg/kg for seven days  to test the nootropic activity by using Y- maze test and locometer activity.After that  examined the histological dissection of rat's brain tissues.

Results:With the Y-maze task, an ethanolic extract of Artemisia roxburghiana demonstrated a greater percentage of spontaneous alteration and an altered behavior response.In locometer activity it is observed that the ethanolic leaf extract of artemisia roxburghiana showed nootropic activity by increasing locometer activity.In histological study, effective regeneration scores were shown using low and high extract doses compared to other groups.

Conclusions:The data suggests that the ethanolic leaf extract of artemisia roxburghiana demonstrated potential nootropic activity.