Formulation and Evaluation of an Phyto-Gel Blend of Typha Domingensis, Turmeric and Aloe Vera for Enhanced Antioxidant, Antimicrobial, Antifungal Efficacy.

Abstract

Background: Typha domingensis, a perennial aquatic plant native to the Americas, is known for its antioxidant properties and antimicrobial effects. Its leaves, flowering parts, seeds, rhizomes, stems, and leaves have been used in traditional medicine for wound healing, weaving, and crafts. The plant's male and female sections prevent bacteria and fungi growth, while curcumin and aloe vera possess antibacterial, antifungal, and antioxidant properties.

Methodology: Phyto-gels are herbal gel formulations that combine various components and active constituents to provide specific effects, such as antibacterial, anti-inflammatory, and wound-healing properties. These gels are popular in wound healing due to their promotion of physiological processes and hastening the healing process. The formulation process involves extracting the herbal extract, choosing excipients, gelling agents, and preservatives.

Results and discussion: Various methods are employed in the production of polyherbal gels, with the dispersion method being the most effective. Physical attributes such as appearance, pH, spreadability, viscosity, and homogeneity are assessed, along with chemical attributes like flavonoid tests. Antimicrobial tests were conducted using the disc diffusion method (Kirby Bauer method) against E. coli and B. subtilis, and the antioxidant test was executed by Hydroxyl radical scavenging activity using the Fenton method with a minor amendment.

Conclusion: In summary, Typha domingensis, Curcumin, and Aloe vera are combined to create an antiseptic Phyto-gel, promoting synergistic effects of antifungal, antimicrobial, and reducing oxidative stress.