Gingival Gene Expression of Endocan as Biomarker of Periodontitis and Diabetes Mellitus – An Invivo Comparative Analysis

Abstract

Periodontal disease is an inflammatory disease that is initiated by microbial infection, subsequently progresses via an aberrant host response, and primarily contributes to periodontal tissue destruction. Studies have revealed possible link between periodontitis and different systemic diseases. Periodontitis and diabetes mellitus are chronic inflammatory diseases with an established bi-directional relationship. It has been well documented that Endocan mRNA levels reported to modulate inflammatory dependent pathways between periodontal disease and systemic diseases.The aim of the present study is to evaluate and compare the level of Endocan  mRNA expression in gingival tissues of periodontally healthy subjects and periodontitis patients with and without type II diabetes mellitus and also to correlate the inflammatory burden (PISA score) with Endocan mRNA expression.