Evaluation of Anti-Ulcer Activity of the Seeds of Oroxylum Indicum in Swiss Albino Mice Against Ethanol-Induced Gastric Ulcer Model.

Abstract

Objectives: The objective of this study is to assess the antiulcer effect of drug Oroxylum indicum in mice with ethanol-induced gastric ulcers. This study aims to evaluate ulcer healing by multiple parameters, including its ability to reduce oxidative stress, inhibit gastric acid secretion, offering a comprehensive understanding of its therapeutic potential.

Methods: The Oroxylum indicum seeds extract was extracted by maceration process, and further phytochemical screening was performed to detect phytochemicals in it. Some in-vitro tests of DPPH and Alkaline DMSO were performed to study the presence of antioxidants in the extract. Also, ethanol-induced gastric ulcer model has been selected for the study using Oroxylum indicum seeds extract at dose of 50 mg/kg, 100 mg/kg and 200 mg/kg. pH of the stomach tissue was measured and also Malondialdehyde and nitric oxide tests were performed.

Results: The results obtained from the data revealed that Oroxylum indicum seeds extract have an antioxidant effect and at a dose of 200 mg/kg 49.53% have the highest healing score as compared to standard pantoprazole 40 mg/kg 57.84%. Histopathological examination shows more ulcers in the disease control group and fewer ulcers were observed in Oroxylum indicum seeds extract group.

Conclusions: The present study concluded that Oroxylum indicum seed extract shows a good anti-ulcer effect at 200 mg/kg dose with its gastroprotective mechanism and antioxidant properties.