Preparation Of 2-Propionylaminobenzimidazole and Its Anthelmintic Activity

Abstract

In current work studied interaction of methylbenzimidazol-2-ylcarbamate with propionic acid. The reaction with propionic acid was carried out by boiling (141°C) of carbamate in excess acid for eight hours It should be emphasized that the reaction in propionic acid, in contrast to acetic acid, proceeds with the formation of a product at the exocyclic 2-propionylaminobenzimidazole yield of is quantitative (96%). The structure of the obtained compound was proved by IR, 1H NMR-spectroscopy and mass spectra.

Based on the synthesized 2-propionylaminobenzimidazole, an effective stable suspension form was obtained for animal husbandry using local raw materials. At the same time, a decrease in the toxicity of the drug was achieved.

The article also contains information on the study of the anthelmintic properties of powder and suspension forms of 2-propionylaminobenzimidazole against ovine helminthiasis. In particular, it was noted that the powder form of the drug gives a high anthelmintic effect against fastsiolosis, nematodiosis and marshallagiosis, which are the main helminthiasis, and the suspension form of the drug has a high anthelmintic property against fastsiolosis of this Code.

The article found that the use of 2-propionylaminobenzimidazole in an amount of 200 mg/kg is highly angelmintic, but not toxic and cumulative for the body of sheep.

At the same time, the article notes that the drug 2-propionylaminobenzimidazole, produced in the Republic of Uzbekistan, is a highly effective anthelmintic agent of a wide anthelmintic spectrum and is a class of vaccine in Nemato and Tremato, which are considered livestock helminths that cause great economic damage to the sheep industry.