Effectiveness of Ozonated Oil and Pro-Argin Formulation Toothpaste Alone and Their Combination in Treatment of Dentin Hypersensitivity: A Randomised Controlled Clinical Split Mouth Study.

Abstract

Introduction: Dentin hypersensitivity is a prevalent dental condition with a prognosis that is predictable but no permanent treatment. There are several alternatives for treating Dentin Hypersensitivity, but it hasn't yet been proven that any of them is better than the rest on their own.

Aim:  To evaluate and compare the effectiveness of Pro-Argin formulated dentifrice and Ozonated oil in the treatment of Dentin Hypersensitivity when used alone and in combination, using placebo as a control.

Methodology: This was a randomized split-mouth clinical trial.  Sixty patients aged 20–60 years suffering from dentin hypersensitivity to air-blast, cold, and tactile stimulation corresponding to 4 cm and above on the Visual Analog Scale (VAS) in four quadrants with at least two hypersensitive teeth per quadrant were selected. Hypersensitive teeth were allotted to Group 1 – Pro-Argin formulation toothpaste application alone, Group 2 – Ozonated oil application alone, Group 3 – Pro-Argin toothpaste application, followed by Ozonated oil, Group 4 – placebo toothpaste application. VAS score was recorded at baseline, immediate and after 4 weeks.

Results: A statistically significant reduction in dentin hypersensitivity was observed in all the four groups, from the baseline and 4 weeks application (P < 0.05). Group 1 and Group 3 demonstrated a significantly higher reduction in dentin hypersensitivity for all the stimuli as opposed to Group 2 at all follow‑up intervals

Conclusion: The study concluded that the combined application of Pro-argin toothpaste and Ozonated oil may provide appreciable clinical therapeutic benefit leading to effective management of dentinal hypersensitivity.