Comparison of Hemodynamic Parameters Between Bupivacaine and Combination of Bupivacaine and Midazolam in Patients Undergoing Lower Limb Surgeries

Abstract

Various intrathecal additives are added to local anesthetics to increase the speed of onset, improve the quality, and prolong the influence of spinal anesthesia. Midazolam has a synergistic effect on postoperative analgesia when administered intrathecally with bupivacaine. Intrathecal midazolam has been reported to have antinociceptive action.4 Evidence indicates that intrathecal midazolam may be useful in the treatment of somatic pain.5,6 The optimum dose of intrathecal midazolam for postoperative analgesia is not identified. In previous studies midazolam has been administered in the dose of 1mg and 2mg intrathecally. Objective: To compare the hemodynamic parameters between bupivacaine and combination of bupivacaine and midazolam. Materials and Methods: The present Descriptive observational study was carried out at Department of anaesthesia with simple Random sampling method. Data entered in MS excel sheet and analysed by using SPSS 24.0 version IBM USA. Results: We included 50 patients in each group. Mean age of the patients from Group B and Group BM was 41.19(13.27) and 36.50(13.70) years. 76% and 84% of the males were from Group B and Group BM. 24% and 16% of the females were from Group B and Group BM. SBP, DBP, SPO2 and RR were comparable in both the groups stating no major effect of addition of bupivacaine in midazolam. Conclusion: We observed no significant difference in the effect of two drugs i.e. bupivacaine and combination of bupivacaine and midazolam on hemodynamic parameters like SBP, DBP, SPO2 and respiratory rate in our study.