A Study on Morphology, Morphometry, And Histological Changes in Normal and Anomalous Human Aborted Fetal Kidney at Different Gestational Periods.

Abstract

The human fetal kidney undergoes intricate developmental processes crucial for establishing proper renal function postnatally. Originating from the intermediate mesoderm, the kidneys undergo nephrogenesis, branching morphogenesis, and tubulogenesis to form nephrons, the functional units. Disruptions in these processes can lead to congenital renal anomalies, impacting renal function and overall health. Understanding fetal kidney development is vital, as abnormalities can predispose individuals to renal disorders later in life. Roughly 20% of fetal congenital malformations are characterized by renal anomalies, emphasizing the need for early detection and management. Elucidating normal fetal kidney development forms the basis for identifying anomalies, with investigations across gestational periods crucial for scientific understanding and clinical applications. This mini-review highlights the significance of studying fetal kidney development, providing an overview of its stages, and emphasizing the importance of recognizing normal and anomalous characteristics.