Effect of Bone Graft and Platelet Rich Fibrin with and Without Alendronate in the Management of Intrabony Periodontal Defect – A Randomized Clinical Study

Abstract

Background: Periodontal disease is characterized by the presence of gingival inflammation, periodontal pocket formation, and loss of connective tissue attachment and alveolar bone around the affected teeth. The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissues, including cementum, periodontal ligament and alveolar bone. The aim of the present study is to evaluate the effect of bone graft and platelet rich fibrin with and without alendronate in the management of intrabony periodontal defect.

Materials and method: Study sample included 20 patients who were randomly divided and treated with one of the following: Site-A open flap debridement followed by placement of platelet rich fibrin (PRF) and bone graft (Perioglas®). Site-B open flap debridement followed by placement of platelet rich fibrin (PRF), alendronate (ALN) and bone graft (Perioglas®). Clinical parameters and radiographic parameters were recorded at baseline and 6 months. Statistical analysis was done using SPSS software.

Results: The results of present study demonstrate that in all the sites there was a significant improvement in clinical and radiographic parameters, thereby improving periodontal status.

Conclusion: Perioglas®, PRF and ALN were all shown to be safe to use and combination therapy with bioactive glass + PRF is also found to be effective. The present study found that adding a single titrated dose of host modulating agent like ALN marginally improved the predictability of bone formation.