Correlation of Fractional Exhaled Nitric Oxide [Feno], Spirometry, and Symptom Control in Childhood Asthma, A Cross-Sectional Study
Main Article Content
Abstract
Introduction:
Childhood asthma is a common respiratory condition, with a challenging symptom management. Fractional exhaled nitric oxide [FeNO] and spirometry are key tools for assessing airway inflammation and lung function, contributing to personalized treatment strategies in pediatric patients.
Aims and Objectives:
To investigate the correlation between FeNO, spirometry, and symptom control in childhood asthma.
Materials and Methods:
This cross-sectional study was conducted at the pediatric respiratory clinic of CHRI from September 2022 to September 2023, with ethical approval and informed consent obtained. Children were evaluated based on symptom control scores per GINA guidelines, followed by spirometry and FeNO analysis. Statistical analysis was performed using SPSS, and Spearman's rank correlation was used to assess relationships between variables, with p<0.05 considered significant.
Results:
Among participants, 13.8% had well-controlled, 70% partly controlled, and 16.3% uncontrolled symptoms. Mean FeNO was 25.2 ± 16.9 ppb, and mean FEV1% was 78.7 ± 13.2%. Significant correlations were observed between FEV1% and symptom control [p=0.0005], FeNO and symptom control [p=0.0005], and FeNO and FEV1% [p=0.005].
Conclusion:
FeNO shows an indirect correlation with symptom control and FEV1%. When spirometry is not feasible, FeNO may provide indirect evidence for asthma management.