Case Report: Angioneurotic Edema Mimicking a Skull Base Lesion

Abstract

Angioneurotic edema, also known as angioedema, is a condition characterized by rapid localized swelling due to fluid accumulation in the deep dermal and subcutaneous tissues. It is typically associated with allergic reactions, hereditary factors, or medication side effects. Skull base lesions, on the other hand, are rare but distinct pathological entities that are usually identified through imaging or biopsy. The overlap between these two conditions is exceedingly rare, leading to diagnostic challenges.

We present a rare case of angioneurotic edema clinically mimicking a skull base lesion. A 51-year-old male presented with acute onset swelling of the soft palate, initially suspected to be a skull base lesion based on clinical findings. Despite typical characteristics of angioneurotic edema, the presentation was atypical, leading to significant diagnostic uncertainty. Detailed clinical history, laboratory investigations, and imaging studies were utilized to differentiate between these conditions.

Clinicians should be aware of the potential for angioneurotic edema to mimic skull base lesions. Comprehensive evaluation, including detailed patient history, laboratory tests, and imaging, is essential for accurate diagnosis and appropriate management. This case underscores the need for heightened awareness and consideration of rare mimickers in differential diagnoses to prevent mismanagement and ensure optimal patient outcomes.