Design, Synthesis and Biological Evaluation of Benzothiazole Derivatives for Antimicrobial Activity

Abstract

Benzothiazoles are a crucial class of heterocyclic compounds known for their broad spectrum of biological activities, particularly their antimicrobial properties. This study investigates the synthesis, molecular docking, and biological evaluation of various benzothiazole derivatives for their potential antimicrobial activity. A series of benzothiazole derivatives were synthesized and characterized using spectroscopic methods. Molecular docking studies were performed to predict the binding affinities of these derivatives to target microbial enzymes, providing insights into their mechanisms of action.

Biological evaluation involved testing the synthesized compounds for their antifungal and antibacterial activities against selected microbial strains. Compounds A1, A2, A4, A6, and A9 demonstrated significant antifungal activity against Aspergillus niger and Candida albicans (NCIM 3102), with Amphotericin-B used as the standard antifungal drug for comparison. Among these, compounds A1, A2, and A9 also exhibited promising antibacterial activity against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 29737), with Ciprofloxacin serving as the standard antibacterial drug.

The results indicate that specific structural modifications in the benzothiazole core can enhance antimicrobial efficacy, suggesting that these compounds have potential as therapeutic agents. Further studies, including in vivo testing and optimization of lead compounds, are warranted to fully explore their clinical potential.