Anti-diabetic Activity of Ethanolic Extract of Rosa Centifolia and Its Purified Fractions
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Abstract
People all over the world have long consumed Rosa centifolia L. as a wild edible herb. The Aim of This study is to explore the antidiabetic activity of ethanolic extract and its fraction of Rosa centifolia L. petals. Four fractions of ethanolic extract (mother extract) were isolated (ME, F6, F6.4, F6.4.2) and were found phytochemical-rich. All four fractions were administered orally which effectively inhibited the elevation of plasma glucose in rats loaded with glucose, and its ethanolic fraction (F6.4.2) exerted significant inhibitory actions in STZ-induced diabetic rats.
Background: Rosa centifolia L. is a native plant of India. The rose petals are used in the food industry to alter the flavor of foodstuffs.
Objectives: The aim of this study to investigate the antidiabetic potentials of flavonoid rich ethanolic extracts of Rosa centifolia petal in type 2 diabetic Wistar albino rats.
Material and methods: Fifty four rats were randomly distributed into nine groups of six animals each with group 1 serving as the normal control. Groups 2 to 7 were given 0.5% CMC in their drinking water for 14 days, after which 60 mg/kg of streptozotocin was administered. Group 2 animals served as the diabetic control, while groups 3, 4, and 5 were treated with, 100 mg/kg plant extract, 250 mg/kg plant extract, and 500 mg/kg plant extract respectively. Groups 6, 7, and 8, were treated with an ethanolic fraction of plant extract 100 mg/kg, 250 mg/kg, and 500 mg/kg glibenclamide respectively. Biochemical parameters such as liver and kidney function tests, lipid profile, as well as lipid peroxidation, and antioxidant enzymes were assessed in addition to histopathology.
Results: It was observed that daily oral administration of MSD and FSD for 14 days significantly (p < 0.05) improved the observed pathological changes as a result of type 2 diabetes.
Conclusion: It could be inferred from results obtained in this study that methanolic and flavonoid-rich leaf extracts of Rosa centifolia have antidiabetic potential in type 2 diabetic rats.