Increasing Trend of Multi-Drug Resistance Enterococci

Abstract

Background: The emergence of Enterococci with multi-drug-resistance has consistently raised concerns among healthcare professionals. They commonly cause urinary tract infection along with blood stream infection, endocarditis, and other nosocomial infections. Enterococcus infections have usually been treated with aminoglycosides and cell wall-active medications; however, as multidrug-resistant strains of the infection have proliferated, the number of effective treatments has dropped. This study aims to ascertain the enterococci's occurrence and vulnerability pattern in clinical samples.

Material and Methods: The Facklam and Collins technique was used to identify 312 Enterococcus that were isolated from different clinical samples. The isolates were subjected to ascertain Van A and Van B resistance with the help of modified Kirby Bauer disc diffusion method

Results: A total of 312 Enterococcus species were obtained from numerous medical samples in which 162 were E. faecalis, 48 of E.avium, and 102 were E.faecium. Resistance to tetracycline, penicillin, ampicillin, ciprofloxacin, and high-level gentamycin were observed. Most of the vancomycin resistant enterococci were observed in urine sample.

Conclusion: A high rate of resistance to tetracycline, ciprofloxacin, high-level gentamycin, and erythromycin was found and the situation was further worsened by the emergence of Vancomycin Resistant Enterococci. We, therefore, suggest that, there should be a strict hospital infection policy and practices along with regular screening for enterococcus. The research emphasizes the significant therapeutic challenge posed by the rise in multidrug-resistant enterococci and their rising prevalence.