Formulation & Evaluation of Niacinamide Liposomes in Aloe Vera Gel

Abstract

This study aims to formulate and evaluate niacinamide-loaded liposomes incorporated into an aloe vera gel base. By combining the advantages of liposomal encapsulation and aloe vera gel, the developed formulation seeks to enhance the stability, skin delivery, and efficacy of niacinamide, providing a superior skincare product for cosmetic and therapeutic applications.

OBJECTIVES: To create a new dosage, form out of novel drug delivery. The study aims to formulate and evaluate niacinamide-loaded liposomes incorporated into an aloe vera gel base to enhance the stability and efficacy of niacinamide for topical application.

Methods: Niacinamide liposomes were formulated using the ethanol injection method and subsequently characterized for their particle size, zeta potential, invitro drug release etc. These liposomes were then integrated into an aloe vera gel base. The resulting formulation was assessed for various physical attributes, including homogeneity, pH, in vitro release behavior & antimicrobial test