Synthesis and Characterization of MgO-loaded Levofloxacin Nanoparticles to Combat Salmonella Typhi bacteria

Abstract

A wide variety of ailments, including cancer, autoimmune disorders, and the colonization of bacteria and fungi, are routinely treated with nanomaterials that contain inorganic metallic ions. These nanomaterials are frequently utilized in the treatment of illnesses. This study was conducted to determine whether or not MgO-loaded levofloxacin nanoparticles (MLFNs) might be potentially utilized as an antibacterial agent. To analyze the nanocarriers that were produced through adsorption, instruments such as FTIR, SEM, and TEM were utilized. To conduct in vitro release studies at a temperature of 37 Celsius, simulated body fluid was utilized. After analyzing the data using a variety of kinetic models, it was found that the dissolution was a glacial process that took anywhere from twelve to twenty-four hours to complete. Through the course of study investigations, it was shown that antimicrobial agents have become more effective in combating Salmonella Typhi. Based on the findings of an experimental examination, it was discovered that MLFNs possessed a particle size of 241 nanometers, a zeta potential value of -40.76 millivolts, and a high encapsulation efficacy of 87-91%. These qualities were uncovered as a consequence of the findings of the experiment