Synthesis of Flavopiridol Analogues Containing 1,3-Thiazolan-4-one and Their Antibacterial Activity

Abstract

The biological and pharmacological importance of flavopiridol and 1,3-thiazolan-4-one and their derivatives, contemplated to synthesize some new flavopiridol analogues containing 1,3-thiazolan-4-ones such as 3-[2-(2-chlorophenyl)-5-hydroxy-4-oxo-4H-8-chromenyl]-2-aryal-1,3-thiazolan-4-one 8 (a-f) has been Synthesized by the reaction of 2-(2-chlorophenyl)-5-hydroxy-8-[(E)-1-arylmethylidene]amino-4H-4-chromenone 7 with a view to explore their potential biological activity. The antibacterial activities of these compounds  have also been evaluated.