Evaluation of Anti-Depressant Activity of Polyherbal Extract of Hibiscus Rosa Sinesis Flower and Carica Papaya Leaf in Rats
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Abstract
Present study investigated the anti-depressant effects of polyherbal extract of Hibiscus Rosa sinesis flower and Carica papaya leaf in wistar albino rats. The plant material was extracted in a soxhlet apparatus using ethanol as solvent. Preliminary phytochemical screening and thin layer chromatographic analysis was done. Wistar albino rats were selected for experimental study. Imipramine 15mg/kg was used as standard drug for the study. Animals were divided into five groups. For evaluation of anti-depressant effect, tail suspension test and forced swim test method used. HRSCP extract at 400mg/kg was significantly reduced immobility time of animals (P<0.05) at day 1st and Day 14th in forced swimming test. Animal treated with HRSCP extract at 200mg/kg significantly reduced immobility time at Day 14th in Tail suspension model (P<0.01) as compared to other group. The present study concluded that, polyherbal extract of Hibiscus Rosa sinesis flower and Carica papaya leaf (HRSCP) at dose dependent manner significantly reduced immobility of animals in tail suspension and forced swim test models and produced anti-depressant effects.
According to the findings, Hibiscus Rosa sinensis flower and Carica papaya leaf extract show promise as an adjunct or alternative therapy for depression, maybe providing a low-cost, all-natural option.