Enhancing Tissue Conditioner Efficiency: A Comparative Study of Antifungal Effects and Surface Roughness with Voriconazole and Itraconazole

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Taniya Bhatia, Madhurima Sharma, Shalabh Kumar, Rohit Sharma, Vishwadeepak Singh, Akash Gopi, Rohit Nandan, Ayushi Piplani, Sakshi Gupta, Gyan Abhishek


Objectives: To evaluate and compare the surface roughness and antifungal activity of a tissue conditioner when combined with voriconazole and itraconazole.

Methods: For this study, one tissue conditioner, two antifungal drugs were used. Before testing, drugs incorporated in tissue conditioner and discs made which were allowed to immersed in distilled water.

Three groups of ten samples each, used to categorize the specimens: Groups I, II, and III were GC Soft Liner (G), GC Soft Liner + Voriconazole (GV), and GC Soft Liner + Itraconazole (GI).

Each group consists of 10 samples. Five assessed for antifungal activity and five for surface roughness. Each disc tested in 1st, 15th and 30th day.

For antifungal activity, zone of growth inhibition measured and profilometer used to test surface roughness.

Results: (i) Statistical significant difference in surface roughness across the three groups observed: Group I-highest, followed by Group III, Group II-least.

(ii) In intragroup comparisons over different time intervals, statistically significant variations observed; Day 30 - highest surface roughness and zone of inhibition, followed by Day 15 and Day 1.

(iii) Statistical significant difference in zone of growth inhibition across three groups was observed, Highest inhibition zone -Group II, followed by Group III, Group I-least.

Conclusion: Voriconazole in tissue conditioner showed significant highest zone of growth inhibition than other two groups. The mean surface roughness of a tissue conditioner used as control-group was suggestively maximum and least with voriconazole in a tissue conditioner.

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