A Review on Parkinson’s Disease and its Management

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Shivani Pandey, Kisalaya Mishra, Dharmendra Singh Rajput


The preservation of neuronal structure and function against insults resulting from cellular damage caused by various agents or neurodegenerative disorders is known as neuroprotection. Amyotrophic lateral sclerosis, Parkinson's, Alzheimer's, and Huntington's are a few of the several NDs that impact millions of individuals worldwide. Primary risk factor for these diseases is growing older. Each of these illnesses has distinct clinical and molecular characteristics and affects certain neurons and/or brain areas. Consequently, a number of in vitro and in vivo experimental models that are unique to each illness have been used to investigate NDs in an effort to comprehend their fundamental processes and discover novel treatment approaches. Parkinson's disease is a complicated neurodegenerative disorder characterized by a progressive loss of function in the nigral dopaminergic neurons of the midbrain. A cure for Parkinson's disease that modifies the illness's pathophysiology is still undiscovered. Herbal remedies have been utilized for hundreds of years to treat neurological diseases throughout Asia, including China and India. This field of medicine has lately gained significant interest due to the development of pharmaceuticals that can cure Parkinson's disease. The pathogenic aspects of Parkinson's disease, proteins clumping together, oxidative stress, ion accumulation, mitochondrial malfunction, and neuroinflammation as well as the latest developments in the field, were originally outlined in this study.

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