https://jchr.org/index.php/JCHR/gateway/plugin/WebFeedGatewayPlugin/atomJournal of Chemical Health Risks2024-03-29T09:38:33+00:00Editor in Chiefeditor@jchr.orgOpen Journal Systems<div class="row"> <div class="col-sm-4"><img src="http://jchr.org/public/site/images/editor_jchr/cover-en-ed328513c60762239f252e05ec8b442c.png" width="100%" height="auto" /> <ul class="list-group list-group-bordered list-group-noicon" style="margin-top: 10px;"> <li class="list-group-item"><a>Articles in Press</a></li> <li class="list-group-item"><a>Current Issue</a></li> </ul> </div> <div class="col-sm-8"> <p style="text-align: justify;"><em>The JCHR</em> as a peer-review professional academic journal is striving to provide the best forum for researchers and scholars worldwide to exchange their latest findings and results.</p> <p style="text-align: justify;"><strong>Our objective is to publish the high quality researches. Therefore, publishing paper in this journal is free of any charge.</strong></p> <p style="text-align: justify;">The journal is a multidisciplinary journal of chemistry, biology and public health will publish original researches and scientific articles describing studies of the toxic effects of chemical agents on human, environment and animal.</p> <p style="text-align: justify;">Chemical Health Risk focuses on information and ideas relating to issues and advances in chemical health and safety.</p> <p style="text-align: justify;"><strong>Research Areas including: </strong></p> <ul style="text-align: justify;"> <li>Toxicology</li> <li>Mineral and Organic Agents</li> <li>Environmental Analysis</li> <li>Occupational Medicine</li> <li>Cancer Research</li> <li>Analytical Chemistry</li> <li>Risk Analysis</li> <li>Pharmacology</li> <li>Biodegradable and Edible Films</li> </ul> </div> </div> <hr /> <div class="row"> <h2 style="background: #193687; color: white; text-align: center; font-size: 20px; padding: 5px;">Most Viewed Articles:</h2> <ul style="font-weight: bold;"> <li style="margin-bottom: 10px;"><a href="http://jchr.org/index.php/JCHR/article/view/34">Trace Metals Content of Soil around a Municipal Solid Waste Dumpsite in Gombe, Nigeria: Assessing the Ecological and Human Health Impact</a><br /> <p style="font-weight: normal;">Mohammad Bashir Sulaiman, Jonnie Niyi Asegbeloyin, Janefrances Ihedioha, Ebube Evaristus Oyeka, Esther Onyinyechi Oji</p> </li> <li style="margin-bottom: 10px;"><a href="http://jchr.org/index.php/JCHR/article/view/197">High-Barrier and Light–protective Bionanocomposite Film Based on Rye Starch/nanorod-ZnO for Food Packaging Applications</a><br /> <p style="font-weight: normal;">Neda Fallah, Mohammad Mehdi Marvizadeh, Reihaneh Jahangiri, Azam Zeinalzadeh</p> </li> <li style="margin-bottom: 10px;"><a href="http://jchr.org/index.php/JCHR/article/view/259">Quantitative Appraisal of Total Aflatoxin in Ready-to-eat Groundnut in North-central Nigeria</a><br /> <p style="font-weight: normal;">Funmilola Sherifat Adefolalu, Daniel Ojochenemi Apeh, Susan B. Salubuyi, Mary Galadima, Augustine Omale Agbo, Michaella Onyinye Anthony, Hussaini Anthony Makun</p> </li> <li><a href="http://jchr.org/index.php/JCHR/article/view/362">Electrospun Nanofibrous Membranes as Potential Adsorbents for Textile Dye Removal-A review</a><br /> <p style="font-weight: normal;">M. Hasanzadeh, B. Hadavi Moghadam</p> </li> </ul> <h2 style="background: #193687; color: white; text-align: center; font-size: 20px; padding: 5px;">Most Downloaded Articles:</h2> <ul style="font-weight: bold;"> <li style="margin-bottom: 10px;"><a href="http://jchr.org/index.php/JCHR/article/view/76">A Comparative Study of the Adsorption Capacity of Tea Leaves and Orange Peel for the Removal of Fe (III) Ion from Wastewater</a><br /> <p style="font-weight: normal;">Kazi Rifat Mamun, Nirob Kumar Saha, Sumon Chakrabarty</p> </li> <li style="margin-bottom: 10px;"><a href="http://jchr.org/index.php/JCHR/article/view/295">New Exact Traveling Wave Solution of Fisher Kolmogorov-Petrovskii-Piskunov Equation for Favorite Genes Spreading by -expansion Method</a><br /> <p style="font-weight: normal;">Mohammad Gholami baladezaei, Morteza Gachpazan, Saedeh Foadian, Hossein Mohammad-Pour Kargar</p> </li> <li style="margin-bottom: 10px;"><a href="http://jchr.org/index.php/JCHR/article/view/139">Effectiveness of Sequential Pre-treatment and Application of High-porosity Hybrid Fly Ash Geopolymer/alginate Adsorbent for the Treatment of Batik Wastewater</a><br /> <p style="font-weight: normal;">Siti Mazatul Azwa Saiyed Mohd Nurddin, Suriati Sufian, Zakaria Man, Nurul Ekmi Rabat, Nazwin Ahmad</p> </li> <li><a href="http://jchr.org/index.php/JCHR/article/view/319">The Effect of Hydroalcoholic Extract of Berberis vulgaris on Wound Healing of Diabetic Wistar Rats</a><br /> <p style="font-weight: normal;">Mansoureh Pashaee, Abdolhossein Shiravi, Vida Hojati</p> </li> </ul> </div>https://jchr.org/index.php/JCHR/article/view/3735Treatment and Analysis of Reverse Osmosis Rejected Water from Industrial Processes2024-03-29T09:38:33+00:00Arlene Abuda Joaquin, Rakesh Namdeti*, Lakhayar Amer Al-Amri, Laila Amor Suhail Said Bait Said, Tafoul Malik Ali Al-Nahari, Tafoul Mohammed Said Al Yafii
<p>This research study delves into the treatment and analysis of reverse osmosis (RO)-rejected water generated from industrial processes. As industries increasingly rely on RO technology for water purification, the management and proper disposal of the rejected water have become critical concerns. This study aims to investigate effective treatment methods for RO-rejected water, emphasizing sustainable and environmentally friendly approaches. The investigation encompasses in-depth analyses of the rejected water, aiming to discern its chemical composition both before and post-treatment. Various treatment methodologies, including simple distillation, fractional distillation, and coagulation using both coagulant alone (Al<sub>2</sub>SO<sub>4</sub>) and coagulant-flocculant (Al<sub>2</sub>SO<sub>4</sub>-polymer) combinations, were employed. The findings indicate that simple distillation proves most effective in reducing pH, turbidity, total suspended solids (TSS), alkalinity, and chlorides in reverse osmosis-rejected water. Conversely, fractional distillation demonstrates superior efficacy in treating conductivity, total dissolved solids (TDS), biochemical oxygen demand (BOD), and hardness. This nuanced approach to treatment underscores the importance of tailored strategies to address specific contaminants within the rejected water.</p>
2024-03-29T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3729To Assess the Hesitancy of Contraceptive Among Women of Reproductive Age Group (19-45 Years) at A Tertiary Care Hospital, Ranchi, Jharkhand 2024-03-29T05:04:40+00:00Shilpa tigga, Shashi Bala Singh
<p><strong>Aim: </strong>The aim of the present study was to assess the hesitancy of contraceptive among women of reproductive age group (19-45 years) at a tertiary care hospital, Ranchi, Jharkhand.</p> <p><strong>Methods: </strong>This was a hospital-based cross-sectional study conducted at outdoor Department of Obstetrics and Gynecology department, Ranchi, Jharkhand. The duration of the study was 6 months. The participants were married females of the reproductive age group (19-45 years). 200 women were included in the study.</p> <p><strong>Results: </strong>A total of 160 (80%) were married and others were single 34 (17%), divorced 4 (2%), and separated, 2 (1%). The levels of education of the women were no formal education, 10 (5%), primary 34 (17%), secondary 96 (48%) and tertiary 60 (30%). 196 (98%) respondents had ever heard contraceptive before, while only 4 (2%) had not. The common contraceptives ever heard about by the women include male condom, natural methods, pills and injectables, IUCD with 198 (99%), 186 (93%), 180 (90%), 172 (86%) and 112 (56%) respectively. The number of women that said family planning commodities were readily available were 152 (76%) but 48 (24%) insist commodities were not readily available. Those that considered the family planning services out of reach suggest; health education 24 (50%), improved supplies 14 (29.16%) and reduction in prices 10 (20.84%) as possible ways to increase availability of the commodities. 140 (70%) women had ever used one form of contraceptive while 60 (30%) had never used any form of family planning.</p> <p><strong>Conclusion: </strong>There is a need to unravel why women refuse contraception for no reason. When such reasons are known, the women can be helped much better. As it is seen in this study, the awareness of modern family planning methods does not translate into use. There are a lot of obstacles to the use stemming from misconceptions. The campaigns for family planning services should aim at the misconceptions in order to drive the demand and remove the barriers. </p>
2023-12-06T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3728A case series describing multisystem inflammatory syndrome associated with acute renal injury in pediatric sars-cov-19 infection.2024-03-29T05:02:32+00:00Sagar Parida, Aparna Aradhana, Braja Kishore Behera, Dillip Kumar Dash, Pawan Prakash, Suchismita Panda
<p><strong>BACKGROUND</strong>: MIS-C (Multisystem inflammatory syndrome in children), is seen post COVID-19 infection with variable patho-physiology and symptoms. Acute kidney injury (AKI) is found to be a common feature in primary COVID-19 infections in adults, but it’s presentation in MIS-C has been rarely described & studied. We first described the 2019 novel coronavirus infection in 10 children occurring in IMS & SUM Hospital,Bhubaneswar, Odisha areas in India. The coronavirus diseases in children are usually mild and epidemiological exposure is a key clue to recognize paediatric case. Prolonged virus shedding is observed in respiratory tract and faeces at the convalescent stage [1].We present a series of 8 critically ill children with multisystem inflammatory syndrome with AKI. Key findings of this syndrome include fever, diarrhoea, shock, and variable presence of rash, conjunctivitis, extremity oedema, mucous membrane changes with acute kidney injury. </p>
2024-02-06T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3727Use of urine reagent strip to evaluate CSF for bedside diagnosis of pyogenic meningitis in paediatric age group: A Hospital Based observational study 2024-03-29T05:00:04+00:00Mrinal Sinha, Mamata Devi mohanty, Braja Kishore Behera, Mrunmay das Mohapatra, Dillip kumar Dash,Tapaswini Samal, Suchismita panda
<p><strong>Background</strong>: Cerebrospinal fluid (CSF) analysis is required to make a diagnosis of meningitis to aid in the proper management of patients. In urban areas with good health-care facilities, it is easy to get a CSF analysis done. However, in rural and remote areas with no proper transport facilities, such a simple point of care test will definitely be useful. We conducted a study and compared the results of reagent strip test with the biochemical tests and microscopic examination.<strong> Aims and Objectives:</strong> The aim of the study was to determine the utility and efficacy of reagent strip test on CSF .<strong>Materials and Methods:</strong> A prospective, time-bound study was carried out department of pediatrics Institute of Medical Science and SUM Hospital, Bhubaneswar, Odisha, India on the CSF sample remaining after the biochemical tests and microscopic examination. The values of both the methods were compared. Using Chi-square and Fischer’s exact test, data were analysed. </p> <p><strong>Results:</strong> Leukocyte esterase positivity by test strip had a sensitivity of <strong>84.6% </strong>and specificity of <strong>51.9%</strong> ,<strong> Positive predictive value=25.6%, Negative predictive value= 94.5% </strong>for detection of CSF granulocytes more than 10 cells/mm<sup>3</sup> . The association of CSF cell count at cut off more than 10 cells/ul was found to statistically significant with presence of bacterial meningitis (p-value =0.005). The sensitivity of glucose strip with trace reading in detection of bacterial meningitis was found to be 92.3%, specificity was 56.4%, positive predictive value was 29.3% and negative predictive value was 97.4%</p> <p><strong>Conclusion:</strong> This test will be useful in remote areas as a point of care test for early patient management. </p>
2024-03-29T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3726Comparative study of intrathecal isobaric levobupivacaine (0.5%) 3ml with dexmedetomidine 0.5ml (5 mcg) and isobaric levobupivacaine (0.5%) 3ml with fentanyl 0.5ml (25 mcg) in patients undergoing surgeries under subarachnoid block: a prospective randomiz2024-03-29T05:00:04+00:00Raghavi.R, Balamurugan B, Saravanakumar.R , Vikasini J
<p>Spinal Anesthesia is the preferred choice for lower limb surgeries due to the benefits of an awake patient, low drug costs, effective intraoperative and excellent postoperative analgesia, and quick patient recovery. Adjuvant must be added intrathecally with low-dose local anesthetics to improve the duration of blockade. </p> <p><strong>Methodology:</strong> A prospective randomized, double-masked study with 60 patients (30 in each group, assigned by computer-generated randomization code). <strong>Group A</strong> ~ (n = 30 ) Patients will receive 3 ml of Isobaric Levobupivacaine 0.5% + Dexmedetomidine 5 mcg (0.5ml) – diluted with NS. <strong>Group B </strong>~ (n = 30 ) Patients will receive 3 ml of Isobaric Levobupivacaine 0.5% +Fentanyl 25 mcg (0.5ml)</p> <p><strong>Results:</strong> The mean time for the highest sensory block among Group A (7.17 ± 5.26) mins and among Group B (5.90 ± 3.52) mins, which did not show statistical significance between both the groups (p-value> 0.05). The mean time for regression of sensory block level up to T 10 among Group A cases was (183.60 ± 56.71) mins and among Group B cases (171.17 ± 53.01) mins, which was found to be statistically insignificant (p-value> 0.05).</p> <p>The mean time of onset of a motor block of Group A (2.35 ± 1.40) & Group B (2.53 ± 1.69) mins was found to be statistically significant between both the groups (p-value < 0.05). It was found that Group A had the fastest time of onset of motor block (Modified Bromage 2) than Group B. The duration of motor blockade in Group A (296.30 ± 75.5) mins and Group B (267.35 ± 23.78) mins was found to be statistically significant between the two groups. (p-value < 0.05), It was found that Group A had the fastest time of onset of motor block (Modified Bromage 2) than Group B. The mean time for first rescue analgesia was significant between the two groups. The time for first rescue analgesia was significantly longer in </p> <p> Group A (6.93 ± 1.47 hours) and Group B (4.78 ± 2.71 hours).</p> <p><strong>Conclusion:</strong></p> <p>The addition of Dexmedetomidine to Isobaric levobupivacaine significantly prolongs the duration of analgesia and anesthesia when compared with fentanyl as an adjuvant to Isobaric levobupivacaine. Levobupivacaine, when administered along with Fentanyl, is a suitable drug for daycare surgeries, while levobupivacaine with dexmedetomidine is an excellent agent for longer-duration surgeries. Dexmedetomidine appears to be an appealing adjuvant to intrathecal local anesthetics compared to opioids. </p>
2024-03-29T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3724Profile of Alcoholic Liver Disease in Patients Attending De-Addiction Tertiary Level Teaching Hospital Jharkhand2024-03-29T05:00:04+00:00Mayank Shekhar, Anish Choudhary, Gautam Gaurav, Biplaw Balraj
<p>In a country like India, with a diverse population, alcohol consumption is acceptable in various societies, so it is important to understand drinking patterns. Alcohol consumption is associated with mental, physical, and socioeconomic problems. This study was performed on 1500 patients attending department radiology, central institutes of psychiatry, kanke, Ranchi, Jharkhand. The study was done to understand the Socio-Demographic Characteristics, type Of Alcohol and Number of Drinks per Day, Clinical presentation of alcoholic liver disease, Biochemical parameters of the patients, and complications occurring due to alcohol consumption. All the data was collected in tabulation format. </p>
2024-03-29T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3723Hepatic Hazards of Quantity and Duration of Alcohol Consumption Patients Attending De-Addiction Tertiary Level Teaching Hospital Jharkhand2024-03-29T05:00:04+00:00Saurabh Chaudhuri, Anish Choudhary, Mayank Shekhar, Biplaw Balraj
<p><strong>Objective</strong>: To study the correlation between duration and quantity of alcohol consumption with biochemical markers and radiological liver function tests in patients coming to tertiary level psychiatric h.</p> <p><strong>Methods</strong>: The study included 1030 patients with a history of alcohol consumption for more than 3 years, presenting to the Central Institute Psychiatry, Radiology Department, Ranchi, Jharkhand, from January 2023 to December 2023. All the male patients in the adult age group with more than 3 years of alcohol consumption were included in this study. A complete hemogram, liver function, and lipid profile were done in each patient. Liver ultrasonography was also conducted. Alcohol Use Disorders Identification Test Results (AUDIT) assessment of excessive alcohol use was done. Results: 14.56 % of patients had hemoglobin < 12 gm., with only 50% of patients having TLC count within the normal range. MCV < 100 was seen in 72.9%, biochemical jaundice in 45.72%, and raised serum GGT in 83%, SGOT in 78.05%, and SGPT in 47.08% was seen. Fatty liver in 67.08% and hepatomegaly in 74.07% were seen in this study. A significant correlation of > 80gm alcohol per day with De arranged liver function test, lipid profile, and radiological findings was observed in this study.</p> <p><strong>Conclusion</strong>: A significant correlation between the quantity and duration of alcohol with liver function tests, biochemical blood markers, and lipid derangements was found in this study. Primary and secondary prevention of alcohol-induced hepatic injury can be done with early detection of the same with blood markers. </p>
2024-03-29T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3716Hyperhomocysteinemia: a variability factor of the daily blood pressure profile in patients with arterial hypertension and excess body weight2024-03-28T11:06:20+00:00Viktoriia S. Potaskalova, Mykola V. Khaitovych, Larisa. V. Natrus, Rostyslav A. Abdryakhymov, Yaroslav. І. Kleban, Maryna S. Savchuk, Vitalii Ye. Lunov
<p>Introduction. Arterial hypertension in patients with excess body weight is associated with a rapid progression of cardiovascular events.</p> <p>The aim. To determine the effect of homocysteine on the daily profile of blood pressure and blood glucose and its dependence on the level of anxiety.</p> <p>Materials and methods. 103 patients (52 women and 51 men) with arterial hypertension and excess body weight were examined. A laboratory blood test, Holter monitoring of blood pressure were conducted, levels of personal and reactive anxiety were determined.</p> <p>Results. The average level of homocysteine in patients was 14.3±6.0 μmol/l, and was 1.6 times higher than in healthy individuals. Hyperhomocysteinemia was found in 37% of patients. On average, they had a higher level of glycemia (6.2±0.9 mmol/l vs 5.7±0.8 mmol/l), average daily systolic blood pressure (128.0±10.7 mmHg vs 121.5±10.1 mmHg) and variability of both systolic (respectively, 18.9±4.4 vs 15.1±2.5) and diastolic blood pressure (16.8±3.5 vs 12.8±1.8); personal (respectively, 43.3±6.3 points vs 38±6.4 points;) and reactive anxiety (38.2±4.6 points vs 34.1±5.2). A mathematical model for forecasting hyperhomocysteinemia in overweight patients has been developed, which allows to identify a group of patients (about 62%) with a high risk of developing complications.</p> <p>Conclusion. Hyperhomocysteinemia was found in 37% of patients with arterial hypertension and excess body weight. These patients were distinguished by higher anxiety, higher blood glucose levels, high variability of the daily blood pressure profile, which increases the risk of cardiovascular events.. </p>
2024-03-28T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3715Comparative Analysis of Serum and Salivary Uric Acid, Albumin and Lactate Dehydrogenase Levels in Smokeless Tobacco Consumers of Sriganganagar Population-A Case Control Study2024-03-28T11:06:20+00:00Samreen Jaral,Basavaraj T Bhagawati, Nishant Kumar, Sharanamma B Bhagawati, Kumari Jyotsana, Isha Balmuchu
<p>Introduction: Oral cancer (OC) is now considered one of the India’s major public health challenges by the World Health Organization (WHO). Oral squamous cell carcinoma (OSCC) is the world’s sixth most common malignancy. Saliva contains a number of biomarkers for the detection of oral diseases. These biomarkers are albumin, lactate dehydrogenase etc.</p> <p>Aims and Objectives: To assess and compare the levels of serum and salivary uric acid, albumin and lactate dehydrogenase levels in smokeless tobacco consumers.</p> <p>Materials and Methods: 25 healthy subjects without any deleterious habits of tobacco or betelnut consumption and without lesion on intraoral examination (Group 1), 25 patients with habit of smokeless tobacco consumption, but without any associated intraoral lesion/(s) clinically (Group 2), 25 patients with habit of smokeless tobacco consumption, and with associated intraoral lesion/(s) seen clinically (Group 3) were included in the study. Levels of serum and salivary uric acid, albumin and lactate dehydrogenase were evaluated using a semiautomatic autoanalyzer. The data obtained was analyzed using the SPSS version 22 software.</p> <p>Results: LDH level in serum increases progressively from group 1 to group 2 and group 3. Salivary LDH value is also increases from group1 to group 2 and 3. Uric Acid level in serum decreases progressively from group 1 to group 2 and group 3. Salivary Uric Acid value is also decreases from group1 to group 2 and 3. Albumin level in serum decreases progressively from group 1 to group 2 and group 3. Salivary albumin value is increases from group1 to group 2 and 3.</p> <p>Conclusion: Estimation of serum and salivary LDH and uric acid is only an auxiliary investigation which may act as an adjunct in diagnosis of OSCC and premalignant lesion and can only provide collaborative evidence.</p>
2024-03-28T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3714Analysis of Outcome of Iastm and Motor Control Training Exercises in Chronic Nonspecific Neck Pain- A Literature Review2024-03-28T11:06:15+00:00Lopa Das, Shefali Raizada, Prem Kumar B. N.
<p>Mechanical Neck pain seems to be the most frequent issue described by many people in their daily life. Neck discomfort has been demonstrated to be a risk factor for decreased general job productivity in young people and is connected with impairment and a much worse quality of life. It is recognized as a medical and socioeconomic burden and one of the frequent reasons behind job absenteeism.IASTM (Instrument Assisted Soft Tissue Mobilization) is a soft tissue manipulation method using a metal instrument over the fascia. Instruments are utilized mechanically to stimulate soft tissue structures during the Instrument Assisted Soft Tissue Mobilization (IASTM) treatment, which reduces musculoskeletal pain and suffering while also enhancing mobility and function. Utilizing an Accel instrument, which was ergonomically created to help doctors identify and treat soft tissue pain, damage, and dysfunction, is a component of this specific method.However, the therapy methods that primarily focus on motor control, activation of deep cervical muscles, and trying to retrain the cervical muscles' ideal control and coordination are the motor control exercises.Primary objective was to assess the outcome of the IASTM and Motor Control Training Exercise program in subjects suffering from nonspecific neck pain which was chronic. Five electronic databases were searched to find the literature (MEDLINE, PubMed, Cochrane, Google Scholar, and CINAHL). The systematic review comprised articles with complete texts that were published between 2013 and 2023, nine of which were studies.</p>
2024-03-12T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3713Acceleration Factors for the Actualization of Behavioural Intentions among Elder Users of Assistive Technologies2024-03-28T11:06:20+00:00Mohd Mazlan Abd Razak, Rosmini Omar
<p>This study aims to identify factors that accelerate the actualization of technology usage behaviour once the behavioural intention is established in the minds of elders. Assistive technologies are the highlights of this study specifically those which are fitted on transportation vehicles that function to bring the elders to various locations from their base homes. This study closely referenced the Technology Acceptance Model (TAM), which emphasizes the two variables Perceived Ease of Use and Perceived Usefulness of technologies which form the key determinants of TAM, and undertakes a Qualitative approach. This study gives evidence to the discovery that there are in existence various factors which accelerate the actualization of behavioural intention of the elders in using Assistive Technologies. Secondly the study also reveals that having mere intentions in the mind need not necessarily result in the actualization of usage of the Assistive Technologies<span style="text-decoration: line-through;">.</span><strong> </strong>The findings of the study suggest a plethora of opportunities for subsequent studies both in the academia and on commercial ventures. Opportunities for further studies may lie in the scope of policy development and regulations for Assistive Technology provision and user participation, and similarly in the commercialization of specific Assistive Technologies for a wider and more economical adoption by the elders. The study further suggests that there are also opportunities in exploring the potential to bridge inter-party roles of the government and the private sector in germinating Assistive Technology products and services to address any known gaps in their usage by the elders. </p>
2024-03-28T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3704Elimination of a Toxic Dye using Avicennia Marina Leaves: Optimization and Modeling2024-03-28T06:27:21+00:00Rakesh Namdeti
<p>In addressing the imperative need to treat toxic dyes in industrial effluent to prevent harm to human health and aquatic life, this study investigates the potential of Avicennia marina leaves as a biosorbent for removing methylene blue from synthetic solutions. Employing a central composite design, the study explores the influence of temperature, pH, sorbent dosage, and initial methylene blue concentration on the dye removal process. The optimal conditions identified include a temperature of 44.3°C, pH of 7.1, sorbent dose of 0.3 g, and an initial methylene blue concentration of 48.4 mg/L, resulting in an impressive 84.26% dye removal. The experimental biosorption percentage under these conditions is found to be 76.93%. The developed artificial neural network (ANN) model successfully predicts outcomes closely aligned with experimental results, showcasing the efficacy of Avicennia marina leaves as a promising biosorbent and the utility of ANN modeling for system optimization and prediction.</p>
2023-12-31T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3701Calculus splint…? A Rare Case Report2024-03-28T11:06:20+00:00Maya Mhaske, Pratiksha Surana, Gargi Deshmukh, Sanket Kapse, Shifa Qureshi, Shashank Deshpande
<p><strong>Introduction</strong>-Periodontal diseases are among the most prevalent diseases. The primary etiological factor for periodontal diseases is dental plaque. Inadequate oral hygiene leads to the calcification of dental plaque and results in the formation of dental calculus. Dental calculus in turn serves as a plaque retentive area, thereby contributing to the establishment of periodontal diseases.</p> <p><strong>Case report-</strong>The present unusual case is of a 24-year-old female patient reported to the Department of Periodontology with a chief complaint of generalized mobile teeth in the upper and lower region. The patient was found to have a very huge calculus mass in the mandibular anterior region and it appeared as a Die section and it was found that the patient was removing teeth 33, 32, and 41 as a unit and fixing them individually again with the help of tongue and calculus over that area to maintain esthetics. Younger generations believe their natural teeth are the most important key to maintaining their appearance. </p>
2024-03-28T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3698Green Synthesis, Characterization and Kinetics of Nano Agro Fertilizer Containing Nanostructured Hydroxyapatite 2024-03-28T11:06:20+00:00Swati Mishra, Anjali Soni
<p>Agriculture is the has been continuously increases with the rapid population growth. Due to high biodegradability and biocompatibility of phosphorus used in the field of insecticide, bio fertilizer, bio pesticide. However, much less progress has been made regarding their application in precision agriculture.</p> <p>Phosphorus is the major plant nutrients of plants. phosphorus is the least accessible since most farmland are frequently phosphorus deficient. Hence, phosphorus use efficiency should be maximized to conserve to resource base and maintain agricultural productivity. The challenge to 66 meet the increasing phosphorus demand in a sustainable manner at a global scale require development of smart solution, modification and improvisation in the chemical properties of fertilizers. Approximately 30 to 65% of total phosphorus present in inorganic form which is not available for plant. According to geographic paper 2020 farmer face many problem related to phosphorus.</p> <p>More soluble phosphorus such as single super phosphate, triple super phosphate polluted water bodies with leads to eutrophication. We use rock phosphorus as the raw material to manufacture fertilizer for this purpose we imports rock phosphorus from UK, China, morocco.</p> <p>This study reported the green synthesis of n-HAP using aqueous seed extract of Cucurbita pepo by wet chemical method because Cucurbita pepo is a common plant in which all parts are editable and rich I Calcium and Phosphorus and phosphorus content and characterized by FTIR(Fourier Transform Infrared Spectroscopy) , SEM( Scanning electron microscopy) and XRD(X-ray diffraction analysis )and study the effect of n-HAP on plant growth. </p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3697Salivary Uric Acid and Catalase Levels in Diabetes2024-03-28T11:06:20+00:00ANANYA RAVIKUMAR, DEVIKA S PILLAI,
<p>is associated with changes in antioxidant enzyme systems and total antioxidant capacity.</p> <p><u>Objective : </u>The aim of this study was to analyse the uric acid and catalase levels in the saliva of patients with type 2 DM and compare them with the healthy control group.</p> <p><u>Methods:</u> In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary antioxidants markers consisted of uric acid (UA) and catalase. Sialo Chemical analysis was performed with spectrophotometric assay. Values were obtained and all the statistical analyses were conducted using SPSS software.</p> <p><u>Results :</u> Salivary Uric acid (3.12 vs. 1.89 mg/dL) was significantly higher (P < 0.001) in patients with DM than healthy controls. Mean UA was approximately 1.7 times higher in diabetic patients than in healthy controls. The antioxidant enzyme catalase showed significantly lower values in the study group than the controls ((1214 vs. 9468.9 kat, P < 0.001), drastic reduction in catalase activity was seen in diabetic samples. The present study demonstrates that antioxidant levels in saliva from diabetic patients exhibit significant differences compared to control samples.</p> <p><u>Conclusion</u>: According to the findings of the current study, patients with type 2 DM showed some alterations in their salivary levels of uric acid and catalase which suggests that there is increase in the oxidative stress levels. </p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3696An Covid-19 Disease Prediction and Analysis Using Sprint Algorithm in Machine Learning Technique2024-03-28T11:06:20+00:00Mrs.V.Ramya
<p>Technology innovation, social media platforms, and online communication play a vital role in balancing human life during the COVID-19 epidemic. Scientists have struggled to predict this disease accurately because of its uniqueness and rapid spread. This is partly caused by variations in human behavior and environmental elements that affect the spread of diseases. However, it spread untruths and misinformation about the disease and the vaccine.The accuracy in determining the covid-19 patients, real news, and fake news becomes very challenging due to widespread and enormous data generation. In our research, we proposed an improved SPRINT algorithm for classifying the correct and incorrect predictions in terms of accuracy.The Histogram and the attribute table are two data structures that the enhanced SPRINT method specifies. The three components of the property sheet are the indexing of attribute value, class identification, and data records. The proposed algorithm is executed in MATLAB code to generate the training model. The accuracy of the proposed system is evaluated with the AdaBoost algorithm with the Random Forest model [16] and with machine learning methods SVM and KNN [17]. The improved SPRINT algorithm shows better results on all the performance metrics than the others. The accuracy obtained by the proposed improved SPRINT algorithm is 99.5% which is far better than the others. </p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3695Fabrication and evaluation of hyaluronic acid and calcium hydroxide and egg shell derived hydroxyapatite GTR membrane2024-03-28T11:06:20+00:00Ananya.R, Balaji Ganesh.S, Rajalakshmanan Eswaramoorthy
<p>INTRODUCTION: Guided tissue regeneration or GTR is a predictable and effective surgical treatment method for regeneration and treatment of periodontal defects. Hydroxyapatite is a calcium phosphate apatite that has been used as graft material with great success. Thus, a novel GTR membrane from HA, Gelatin and eggshell-derived hydroxyapatite could be beneficial in bone remodelling and in the treatment of periodontal defects among periodontally compromised patients whose bone formation levels are affected due to age or other factors.</p> <p>MATERIALS AND METHOD: Eggshell-derived hydroxyapatite was fabricated by calcifying the eggshells at 900 degrees Celsius, adding 0.5M diammonium hydrogen phosphate solution and drying it at 100 degrees Celsius overnight. GTR membrane was prepared and the samples were then assessed for tensile strength, contact angle SEM and FTIR.</p> <p>RESULTS: The average contact angle of the control sample is 70.01°. 0.5% EHA GTR membrane shows an average contact angle of 68.12° and 1% EHA GTR membrane shows an average value of 71.05°. In our study, it was seen that the fabricated samples showed similar contact angles to the control. All the peaks of EHA were assessed on the FTIR spectrum of EHA-HA gelatin membrane which indicates the successful mediation of EHA into the sample.</p> <p>CONCLUSION: Eggshell-derived hydroxyapatite is a versatile and novel bone graft substitute that showed promising results within the study limitations. It is a safe synthetic graft substitute that exhibits good physical properties and is cost-effective and economical. </p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3694Improved Organometal Halide Perovskite Solar Cell Performance via Morphological Control and Substrate Parameter Optimization2024-03-28T11:06:20+00:00Sunil Kumar, Dumendra Verma, Aloke Verma
<p>This research presents a comparative analysis of solar cells utilizing organometal halide perovskite, with titanium dioxide (TiO<sub>2</sub>) and zinc oxide (ZnO) employed as electron transport materials (ETMs). Utilizing SCAPS-1D simulations, the study investigates the influence of absorber and ETM thickness, interface trap density of states, and dopant concentration on photovoltaic solar cell performance. The findings reveal that increasing the thickness of the MAPbI<sub>3</sub> perovskite layer up to 700 nm enhances power conversion efficiency (PCE), while thickness increments beyond 90 nm for TiO<sub>2</sub> and ZnO layers diminish efficiency. The research underscores the importance of controlling the morphology of CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> perovskite solar cells (PSC) for achieving high efficiency and explores experimental and theoretical approaches to attain efficiencies of up to 29%. Additionally, the study examines the significance of optimizing thickness, reducing defect density, and incorporating a back contact with a higher work function, suggesting that replacing the TiO<sub>2</sub> layer with a ZnO layer could enhance solar cell performance</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3693Assessment of Salivary Stress Marker (Peroxidase) Levels in Completely Edentulous Patients: crosssectional study 2024-03-28T11:06:20+00:00R.Ananya, Subhabrata Maiti, Selvaraj R, Dhanraj.M.Ganapathy, Jessy P
<p><strong>BACKGROUND : </strong></p> <p>Patients' diet quality and nutritional status decline as a result of their avoidance of hard meals, including both vegetables and non-vegetables, due to their reduced ability to chew due to tooth loss. Peroxidases are either directly or indirectly associated with several major human disorders, including cancer, periodontal disease, convulsive illnesses, Parkinson's disease, and coronary artery disease (CAD). These diseases can arise as a result of a variety of different chemicals that are involved in the metabolic pathways of peroxidase action, such as auto-antibodies, flavonoids, and thiocyanates. Recent research provides indirect support for the notion that dental implant therapy-based oral rehabilitation is beneficial for people with diabetes. In both diabetic and non-diabetic fully edentulous individuals, we assessed salivary glucose levels to see if the diabetic patient may have any detrimental effects on issues after surgery, implant failure, and peri-implantitis.</p> <p><strong>AIM:</strong> The present study aims to evaluate the peroxidase levels in completely edentulous patients.</p> <p><strong>MATERIALS AND METHOD: </strong>Add the sample and reagent into each well of the human lactoperoxidase ELISA kit. At 37 degrees, incubate for one hour. Rinse the plate five times. Combine solutions A and B for the substrate. Incubate at 37 degrees for ten minutes. Colour develops when a stop solution is added. Within ten minutes, determine the OD density value.</p> <p><strong>RESULTS AND DISCUSSION: </strong>According to the current investigation, there was a statistically significant difference in the groups' baseline means (p=0.00). Patients with diabetes had a mean value of 3.09, and for those with diabetes, it was 2.77, both of which are statistically significant.</p> <p><strong>CONCLUSION: </strong>A significant increase was observed in peroxidase levels in the completely edentulous patients but an elaborate study needs to be conducted with a larger sample size. </p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3691Educator Competency and Capacity Development Model in the 21st Century Era (Study of Principal and Teacher Leadership Models in the Indonesian National Education Program "Merdeka Belajar")2024-03-28T11:06:20+00:00Idi Jahidi, Desi Indrawati
<p>The era of the 21st Century and Society 5.0 impacts all countries, including Indonesia, which is competing to improve various fields of life, economy, socio-cultural, politics, defense, security, and others. In addition to facing the demands of the 21st century and society 5.0, Indonesia has also experienced a learning crisis over the past 10-15 years, which has resulted in education falling further behind with learning loss and increasing learning gaps between regions and socio-economic groups. The COVID-19 pandemic exacerbates this situation. In this paper, the author examines conceptually and empirically how Indonesia is improving to restore the condition of education so that the vision, mission and objectives of Indonesian National Education can be achieved. The Indonesian government restored this learning through the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia launched the "Merdeka Belajar Program" episode 15: Independent Curriculum and Independent Teaching Platform. Implementing the Merdeka Belajar Program is supported by developing the competence and capacity of educators with the leadership model of principals and teachers. Principals and teachers have clear roles and functions in managing educational potential and resources effectively and efficiently to optimally develop students' potential, initiative, ability, and independence. Principals and educators are both leaders, namely principals as leaders of education units and educators as leaders in the learning process. Both must have the competence and capacity to fulfill their duties and obligations following their respective roles and functions.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3689Enhancing Hospital Performance with Patient Centered Care and Safety Management by Empowering Knowledge Management Through Hospital Collaboration: A Comprehensive Analysis in Indonesia2024-03-28T11:06:20+00:00Johanes Ronaldy Polla, Harjanto Prabowo, Sutoto, Bramantoro Abdinagoro
<p><strong> </strong>This paper investigates the profound impact of PCC (Patient-Centered Care) on hospital performance and explores the role of hospital collaboration in promoting Patient-Centered Care adoption in the Indonesian healthcare context. By empowering knowledge management and implementing it with consideration of its complexity in Indonesian hospitals, healthcare systems strive to provide high-quality and patient-centric services. Understanding the dynamics of Patient-Centered Care and its interplay with collaborative efforts becomes paramount. Drawing on a comprehensive analysis of hospitals across Indonesia, this study employs a mixed-methods approach to examine the relationship between Patient-Centered Care and various performance indicators, including patient satisfaction, clinical outcomes, and operational efficiency, as well as collaboration in different types of hospitals in Indonesia (Type A, Type B, and Type C) and their complexities. By analyzing both quantitative data from hospital records and qualitative insights from healthcare professionals, administrators, and patients, a nuanced understanding of the benefits and challenges associated with Patient-Centered Care implementation is garnered. Furthermore, the paper delves into the pivotal role of hospital collaboration as a facilitator for effective Patient-Centered Care delivery. Collaborative efforts among healthcare institutions, including knowledge sharing, interdisciplinary coordination, and resource pooling, can significantly amplify the positive outcomes of Patient-Centered Care. The study investigates the mechanisms through which collaborative networks influence the adoption and sustainability of Patient-Centered Care initiatives, shedding light on the strategies that foster a culture of patient-centeredness within diverse hospital settings. In the context of Indonesia's diverse healthcare landscape, characterized by varying levels of resources and infrastructure, this research identifies contextual factors that impact the successful integration of Patient-Centered Care and collaboration. It also highlights potential barriers such as organizational resistance, communication gaps, and limited resources, proposing recommendations for addressing these challenges. The findings of this study have implications for hospital administrators, policymakers, and healthcare practitioners seeking to enhance patient-centered care delivery and overall hospital performance. The insights generated contribute to the global discourse on healthcare transformation and emphasize the significance of collaboration in advancing patient-centered approaches, ultimately improving healthcare outcomes and patient experiences in Indonesia and beyond.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3688Improving Maternal Health: An Extensive Analysis of ANM's Critical Involvement in Birth Preparedness and Complication Readiness (BP/CR) for Safe Motherhood-A Comprehensive Review2024-03-28T11:06:20+00:00Monalisha Pal, Tushar Singh, Hemlata Lalia, Anugrah Thomas, Subhalaxmi Nayak, Neha Karn
<p><strong>Introduction</strong>: A preparation for a typical delivery and being ready for any emergency that may occur is called delivery Preparedness and Complication Readiness, or BPCR. To ensure that a pregnant woman has access to professional obstetric health services when labour starts, it entails proactive planning and decision-making for the moment of birth. These consist of several little actions that, when taken collectively, have a significant impact on enhancing maternal health and lowering maternal mortality. This review critically examines the pivotal role of Auxiliary Nurse Midwives (ANMs) in ensuring safe motherhood through birth preparedness and complication readiness (BP/CR) strategies. By analysing existing literature, this paper underscores the importance of ANMs in improving maternal health outcomes, particularly in low-resource settings. Through a comprehensive review of relevant studies, policies, and programs, the review highlights the multifaceted responsibilities of ANMs and their critical involvement in BP/CR initiatives. Moreover, the paper identifies key challenges faced by ANMs and offers recommendations for empowering them to effectively fulfil their role in promoting safe motherhood.</p> <p><strong>Objectives</strong>: This comprehensive review aims to analyse the pivotal role of Auxiliary Nurse Midwives (ANMs) in facilitating birth preparedness and complication readiness (BP/CR) to ensure safe motherhood. By examining existing literature, guidelines, and practices, the review seeks to evaluate the significance of ANMs in maternal healthcare systems worldwide, investigate the components of birth preparedness and complication readiness (BP/CR) and their impact on maternal and neonatal outcomes, examine the challenges and barriers faced by ANMs in delivering effective BP/CR services, and explore successful strategies and interventions employed by ANMs to enhance BP/CR and maternal health outcomes.</p> <p><strong>Methods</strong>: A systematic search was conducted across electronic databases such as PubMed, Google Scholar, MEDLINE, and relevant organizational websites (e.g., WHO, UNFPA) using keywords such as "Auxiliary Nurse Midwives," "Birth Preparedness," "Complication Readiness," "Maternal Health," and variations thereof. The search was limited to articles published in English within the last ten years (2014-2024) to ensure relevance. Data Extraction and Synthesis done with relevant data, including study design, population characteristics, key findings, and recommendations, were extracted from selected articles and synthesized to identify common themes, trends, and gaps in the literature.</p> <p><strong>Results</strong>: Gaps in Research and Practice: Despite the progress made, there are notable gaps in research and practice regarding ANMs' involvement in BP/CR. Limited evidence exists on the long-term effectiveness of BP/CR interventions, especially in diverse settings. Moreover, the perspectives of ANMs themselves and the communities they serve are often overlooked in program design and evaluation.</p> <p><strong>Conclusions</strong>: Based on the findings, recommendations are provided for policymakers, healthcare providers, and stakeholders to strengthen ANMs' role in promoting safe motherhood through BP/CR initiatives. These include investing in comprehensive training programs, improving access to essential resources, addressing systemic barriers, and fostering multi-sectoral collaboration to enhance maternal healthcare delivery.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3687Impact of Clinical Pharmacists Mediated Counselling on the Glycemic levels of Diabetic Foot Patients: A Prospective Observational Study2024-03-28T11:06:19+00:00Ritika Bhagat, Tapan Yadav, Jay Patel, Abhay Dharamsi, Priyanshi Shah, Madhavan Iyengar
<p><strong>Introduction</strong>: Diabetic foot is one of the most devasting and lethal complications of diabetes mellitus wherein clinical pharmacists play a huge impact in improving the glycemic level and thus improving the quality of life of these patients.</p> <p><strong>Objectives</strong>: To assess the Impact of Clinical Pharmacist-mediated counseling on HbA1C, Knowledge, Attitude, Practice (KAP), Quality of Life (QOL) and Hospital Anxiety Depression Scale (HADS).</p> <p><strong>Methods</strong>: A baseline comparison study was conducted on 360 diabetic foot subjects in a tertiary care teaching hospital to evaluate the effect of above-mentioned intervention by clinical pharmacist over a period of 1 year. Subjects were counseled and the data were obtained at baseline (visit 0) and follow-up after 3 months (visit 1). KAP, QOL and HADS were assessed by KAP questionnaire, The Diabetic Foot Ulcer Scale- short form and Hospital Anxiety Depression Scale respectively. Along with that HbA1C was also assessed pre and post-impact.</p> <p><strong>Results</strong>: A total of 348 subjects completed the study follow-up. Pre & post KAP, QOL, HADS scores were improved significantly from baseline to follow-up. Thus, HbA1C was also improved.</p> <p><strong>Conclusions</strong>: This study presents that clinical pharmacist plays a pivotal role in improving the patient's condition with diabetic foot in terms of KAP, QOL, HADS as well as HbA1C levels.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3686“A Study to Find Out Normative Reference Values for 10 Meter Walk Test for Normal Healthy Individuals in India- An Observational Study”2024-03-28T11:06:19+00:00Nidhi Katharani, Vishwa Bengali, Manan Mehta, Janavi Bhimajiyani, Navdeep Chopda
<p><strong>BACKGROUND: - </strong>The 10-meter walk test (10MWT) is a simple assessment to measure locomotor capacity in clinical and research settings. Walking speed is associated with several health-related outcomes. Factors that influence walking ability can be classified into six main physiological subsystems: central nervous system, perceptual system, peripheral nervous system, muscles, bone and/or joints, and energy production and/or delivery.</p> <p><strong>AIMS AND OBJECTIVE: -</strong> To find out normative value for 10-meter walk test for normal healthy Indian individuals.</p> <p><strong>METHODOLOGY: - </strong>400 subjects were taken on the basis of inclusion and exclusion criteria. Each subject was made to perform the test on a walkway of 10 meter in which the time required to cover the distance was noted. Demonstration about the test measures were done and each subject instructed to walk at a comfortable (Normal Pace) and Fast Pace (As Fast as they could safely without running) for 10 meters. The Calculation of time was done for 6 meters only. 2 meters in the beginning was considered as acceleration phase and at the ending was considered as deceleration phase and hence were not calculated. Speed was calculated from time used to cover distance.</p> <p><strong>RESULT: - </strong>The mean value of gait speed with normal pace in age group 20-30 year is 2.18±</p> <p>0.33 and maximum 2.80 ± 0.51, normal pace in age group 30- 40 year is 1.97 ± 0.29 march and maximum pace mean value is 2.51 ± 0.44, normal pace in age group 40- 50 year is 1.88 ± 0.31 and maximum pace mean value is 2.34 ± 0.4, normal pace in age group 50- 60 year is 1.90 ± 0.43 and maximum pace mean value is 2.38 ± 0.51, normal pace in age group more than 60 years is 1.50 ± 1.50 & with maximum pace 1.79 ± 1.79.</p> <p><strong>CONCLUSION</strong>: - Present study has established normative reference value for Indian population in age group 20-60 years.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3685Exploring Traditional Wisdom: Antipsychotic Properties of Ethano Medicinal Plants in the Cucurbitaceae Family2024-03-28T11:06:19+00:00Trayambica Acharya, Rupali Rupasmita Rout, Satish Kanhar, Diptimayee Jena, Kirtimaya Mishra, Ashirbad Nanda
<p>Psychosis is a frequent and severely handicapping symptom of many psychiatric, neurodevelopmental, neurologic, and medical diseases. Schizophrenia is a mental illness that results in abnormal behaviours, decreased affect, and altered thought and perception. The neurotransmitter most closely linked to the pathogenesis of psychotic illnesses is dopamine. Dopamine overproduction in the mesolimbic tract is thought to be the main factor of the positive symptoms of psychotic disorders. Additionally involved is glutamate, an excitatory neurotransmitter. The leguminous plant Mucuna pruriens (MP), which thrives in all tropical regions and contains levodopa, was looked into as a possible levodopa substitution for Parkinson's disease sufferers. Polyphenols found in herbal drugs contribute to this regulation of depression. Clinical studies suggest that proinflammatory cytokines, those are available in polyphenols, may contribute to the pathophysiology of depression. According to a phytochemical examination of numerous secondary metabolites, phytocomponents include anthraquinone, flavonoids, steroids, tannins, saponins, alkaloids, terpenoids, and cardiac glycosides are present.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3684 “Compare the Nutritional Status and Dietary Diversity of Rural and Urban School Aged Children in Bagalkot, Karnataka.”2024-03-28T11:06:19+00:00Chetankumar Kalagi, Utalbasha N. Dhandargi, Deelip S. Natekar
<p>Background: In India there persists a huge difference between urban and rural life. The children in their school age explore and experience new things that directly or indirectly influence their health. One of such things in diversity in their diet.</p> <p>Objective: the aim of the study was to compare the nutritional status and dietary diversity of rural and urban school aged children, Bagalkot, Karnataka.</p> <p>Method: Two samples were selected by stratified random sampling technique. One from rural primary school (N= 274) and another from urban primary school (278). The data was collected by structured questionnaire and FANTA dietary diversity tool. Chi square test was used to determine the difference between dietary diversity and Mann Whitney’s test was used to compare nutritional status.</p> <p> Result: the mean age of urban children was 9.18 ± 2.12 years and mean age of rural children was 9.09 ± 2.22 years. There was no significant difference found between dietary diversity of urban and rural children. A significant difference (P< 0.002) was found in weight for age of rural children and urban children.</p> <p>Conclusion: The availability of diet in rural and urban area is similar. There is significant difference in nutritional status in terms of weight for age of rural and primary school children.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3683Evaluation of Pharmacognostical, Phytochemical and In-Vitro Antioxidant Activity of Clerodendrum Colebrookianum Stem Extract2024-03-28T11:06:19+00:00Ramen Kalita, Debabrata Nath, Satyasish Sandilya, Satyendra Deka
<p><strong>Introduction</strong>: The dependence on plant-based healthcare in developing nations arises from issues accessing allopathic medicine and concerns over its side effects. Traditional herbal remedies are assumed as safe and culturally inherited and are highly accepted as seen in Egypt's primary healthcare system. However, the preservation of this traditional knowledge is crucial due to its vulnerability over time. Globally, there's a renewed interest in herbal medicine, driven by safety concerns surrounding synthetic products. India, with its rich herbal heritage documented in texts like Ayurveda illustrates this resurgence. Recognizing and preserving traditional medicinal knowledge alongside scientific research on herbal products is essential for global healthcare. One such medicinal plant, <em>Clerodendrum colebrookianum</em>, known as "Nefafu" is prevalent in India's North-Eastern states. It holds significant traditional medicinal value, utilized for treating various ailments such as hypertension, cough, dysentery and skin diseases, emphasizing its importance in regional healthcare practices.</p> <p><strong>Objectives</strong>: This study explores the pharmacological potential and traditional significance of <em>Clerodendrum colebrookianum</em> (Nefafu) as a medicinal plant, particularly focusing on its antioxidant activity.</p> <p><strong>Methods</strong>: The research focuses on the therapeutic potential of the plant through extensive phytochemical screening and antioxidant assays such as DPPH radical scavenging and Hydrogen Peroxide activity. Additionally, the total phenolic and flavonoid content of the extract was determined.</p> <p><strong>Results</strong>: Phytochemical analysis revealed the presence of alkaloids, saponins, tannins, phenols and fixed oils, aligning with its traditional medicinal use and suggesting new paths for pharmaceutical applications. The antioxidant assays demonstrated notable scavenging effects with an IC<sub>50</sub> value of 155.27µg/ml in DPPH radical scavenging activity, indicating its efficacy in combating oxidative stress. While the test sample exhibited slightly higher percentage inhibition than ascorbic acid at lower concentrations, the latter demonstrated stronger and more consistent inhibition at higher concentrations as evidenced by an IC<sub>50</sub> value of 669.7 µg/ml in Hydrogen Peroxide scavenging activity.</p> <p><strong>Conclusions</strong>: This analysis positions <em>Clerodendrum colebrookianum</em> as a promising candidate for further exploration in contemporary herbal medicine bridging traditional use with modern scientific validation.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3682A Novel Drug Delivery System Through Quantum Dots in Pharmaceutical Applications -A Review2024-03-28T11:06:19+00:00G.Surendra, Sathvik B. Sridhar, M.Ramakrishna Reddy, Srikala Kamireddy, Ch K V L S N Anjana MALE, Kota Sandhya, D Veeresh
<p>Owing to their small size and quantum confinement effects, semiconductor nanoparticles called quantum dots (QDs) exhibit unique electrical and optical capabilities. QDs have been studied for drug delivery, bioimaging, and sensing for pharmaceutical applications. QDs may be used in customized medicine in the future. Targeting disease biomarkers with QDs improves diagnosis and treatment. QDs can also be employed with other nanoparticles in multifunctional drug delivery and imaging systems. Targeted drug delivery systems can be prepared by coating the QDs with biocompatible polymers. Due to their intense fluorescence, QDs can also be utilized as contrast agents in bioimaging. They are promising for various applications, including biomedicine, because of their narrow emission spectra, high brightness, and long-term photostability. Dots have enormous medicinal potential owing to their unique features. Their use in drug delivery, bioimaging, and sensing has been extensively studied, and their future application in personalized medicine is promising. Further research is needed to address concerns about their toxicity and investigate alternative ingredients for their synthesis.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3681Bioactive Compounds from Pleurotus Ostreatus: Unlocking Immunomodulatory, Antioxidant, Antimicrobial, And Anti-Tumor Activities2024-03-28T11:06:19+00:00Sharon Benita Stephen, Rashmi Pauline, Saranya Velmurugan, Bibin Savio Antony, Santhosh Kumar Yasam, Gowtham Kumar Subbaraj
<p>The present review paper examined the nutritional and therapeutic properties of mushrooms as well as their other uses. Throughout human history, mushrooms have played significant roles as food, medicine, legands, folklore, and religious objects. Lately, they have gained popularity as a healthy diet and as a source for medicine development. Numerous physiologically active substances found in many higher mushrooms have been shown to have potential effects on cardiovascular health, hepatoprotection, anticancer and immunomodulation, antiviral and antibacterial properties, hypocholesterolemia and antitumor activities. Because of its remarkable ligninolytic capabilities, the Pleurotus genus<em> </em>is one of the most researched white-rot fungus. In addition to being edible, this fungus offers a variety of biological benefits since it possesses significant amounts of bioactive compounds. Some mushroom species that are often consumed can produce quantities of vitamin D that are significant to nutrition when they are subjected to ultraviolet (UV) radiation, such as sunlight or UV lamps. This review shows that the available data about how UV light affects mushrooms' ability to store more vitamin D2 and we discuss the issues with the pharmacological applications of mushrooms and their bioactive compounds.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024 https://jchr.org/index.php/JCHR/article/view/3680 “A Comparative Study to Assess Oral Health Status among Tobacco Consumers and Non-Tobacco Consumers of Middle Age Adults in Selected Rural Areas of Bagalkot, Karnataka, India.”2024-03-28T11:06:19+00:00Sangamesh, Krutika, Sangeeta, Asif, Roopa, Jagadish M Hiremath, Deelip S. Natekar
<p><strong>Introduction</strong>: Oral health is the practice of keeping the oral cavity clean and free of disease and other problems by regularly brushing teeth and practicing good hygiene habits. The tobacco epidemic is one of the biggest public health threats the world has ever faced to date. Tobacco use being a major risk factor for a number of chronic diseases. It is one of the most important causes of death and disease globally.</p> <p><strong>Objectives</strong>: To assess oral health status among tobacco consumers and non-tobacco consumers of middle age adults in selected rural areas of bagalkot.</p> <p><strong>Methods</strong>: A cross sectional design was used and a sample of 200 middle age adults were selected by convenient sampling technique. The data was collected by using Steps oral health module<strong><em>.</em></strong> The data was entered in MS excel sheet and transferred to SPSS 25 for statistical analysis.</p> <p><strong>Results</strong>: Among 200 samples 58% were males and 42% were females. Among 200 participants 62.5% used to consume tobacco and 37.5% did not consume tobacco. Among Tobacco users 34.4% were 55 & above years of age. A significant difference( P< 0.000) in mouth dryness , persistent wound and/or swelling in the mouth for more than 3 weeks, a red or white patch in the mouth , felt tense because of problems with teeth or mouth , embarrassed about appearance of teeth, sleep is often interrupted due to oral health, during the past 12 months teeth, gums or mouth pain or discomfort and difficulty in chewing food was found between tobacco consumers and tobacco non consumers and a significant difference( P< 0.003 ) in avoiding to smile because of teeth or mouth due to oral health between tobacco consumers and tobacco non consumers was found.</p> <p><strong>Conclusions</strong>: Age, Gender, and Education, increase the risk of tobacco use. The tobacco consumer’s prohibitor strategies must be strengthened to reduce the prevalence of tobacco use among middle age adults.</p>
2024-03-27T00:00:00+00:00Copyright (c) 2024