Development and Evaluation of Nanosized Risperidone Loaded Mucoadhesive Bioflexi Film by using biopolymers of Psidiumguajava (Guava) and Musaacuminata (Banana) for Oro Trans Soft Palatal Delivery

Abstract

Formulation and evaluation of nanosized risperidone loaded mucoadhesive bio-flexy films using novel biopolymer isolated from Psidium guajava and Musa acuminata for schizophrenia treatment, by using orotranssoft palatal route. Trans soft palatal delivery system is an attractive approach for drug delivery system possess advantages as a bypass of the first-pass metabolism, prevent from digestive enzymes and rapid action of suitable drugs. The isolated biopolymer was subjected to various physicochemical characterization procedures. Risperidone was nanosized using sonication methods. Nanosized risperidone loaded bio-flexy films containing isolated Psidium guvaja and Musa acuminata biopolymers were prepared by Film Solvent Casting Technique. Formulations containing different ratios of drug and polymers using Optimized quantity of Dextrose. Evaluation parameters for biopolymers and bioflexy films were performed as Thickness, Folding Endurance, Surface pH, Weight Uniformity, Percentage Moisture Uptake (PTU), in vitro release etc. The bio-flexy film prepared using risperidone: Musa acuminata biopolymer in ratio of 1:5 and risperidone:Psidium guajava biopolymer in ratio of 1:5,both were taken as Best film.Prepared formulations of risperidone loaded bio-flexy films containing biopolymers were appropriate for Soft Palatal Delivery as it showed significant drug release due to its bio-polymeric nature