A Smart Approach for Delivering of Risperidone using Vigna radiata to Prepare Bioflexi film for Oro Trans Soft Palatal Delivery

Abstract

Objective: The purpose of the present study was to formulate and evaluate nanosized risperidone loaded mucoadhesive bioflexi films for effective treatment of atypical antipsychotic. For the preparation of bioflexi films, biopolymer was isolated from seeds of Vigna radiata (Moong Daal). After the extraction of biopolymer, it was subjected for various evaluation parameters.

Methods: A novel method is used for the nanosizing of risperidone and after that bioflexyfilms were prepared by using different ratio of drug and biopolymerusing dextrose as flexicizer and tween 80 as permeation enhancer. After the preparation of different formulations every formulation was studied for different evaluation parameters to find out the best drug polymer ratio.

Results: The formulations were characterized including uniformity of weight, drug content, folding endurance, and thickness. To study the stability of the formulations and in vitro dissolution of the experimental formulations were performed to determine the amount of risperidone present in the film and scanning electron microscopy of the prepared bioflexi films was taken to see the drug distribution pattern. Drug-excipient interaction studies were carried out using UV spectroscopic technique by using wet method and dry method. In vitro dissolution studies showed that the drug distribution in the bioflexi film was homogeneous and it was found that the maximum drug release in 24 h with RVR 6. In vitro skin permeation study was also conducted in a modified Franz’s diffusion cell which shows that the maximum permeation with the formulation RVR 6

Conclusion: The bioflexifilms were found to be suitable for formulating as per the characterization and there was no interaction found between the drug and polymer.